DegronMD

Uniprot ID: Q6GPH4

Source protein: XIAP-associated factor 1

Source gene: XAF1

Class: LIG_APCC_ABBA_1

Location: 220:225

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7671

ASA_SCORE: 96

COIL: 0.8548

CONS_SCORE: 0.186

DSS_SCORE: 0.6931

HELIX: 0.115

FCONS_SCORE: 0.6235

RIG_SCORE: 0.631

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H223Y	TCGA-EE-A182	SKCM	TCGA	FPLHSE	LIG_APCC_ABBA_1	0.6118
p.H223Y	DO37814	SKCM	ICGC	FPLHSE	LIG_APCC_ABBA_1	0.6118
p.P230S	EFO-21	ovary	COSMIC	FPLHSE	LIG_APCC_ABBA_1	0.3056
p.A231T	TCGA-QB-A6FS	SKCM	TCGA	FPLHSE	LIG_APCC_ABBA_1	0.1667
p.A231T	DO48654	SKCM	ICGC	FPLHSE	LIG_APCC_ABBA_1	0.1667
p.R233K	TCGA-AP-A1DV	UCEC	TCGA	FPLHSE	LIG_APCC_ABBA_1	0.1111
p.R233K	DO43186	UCEC	ICGC	FPLHSE	LIG_APCC_ABBA_1	0.1111
p.P212Q	SIDM01078	Small Cell Lung Carcinoma	GDSC	FPLHSE	LIG_APCC_ABBA_1	0.1111
p.P212Q	ACH-000790	Lung Cancer	CCLE	FPLHSE	LIG_APCC_ABBA_1	0.1111
p.P212Q	SHP-77	lung	COSMIC	FPLHSE	LIG_APCC_ABBA_1	0.1111
p.S234G	TCGA-17-Z014	LUAD	TCGA	FPLHSE	LIG_APCC_ABBA_1	0.0833
p.R211C	SIDM00072	Non-Cancerous	GDSC	FPLHSE	LIG_APCC_ABBA_1	0.0833
p.R211C	ACH-000206	Lymphoma	CCLE	FPLHSE	LIG_APCC_ABBA_1	0.0833
p.R211P	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	FPLHSE	LIG_APCC_ABBA_1	0.0833
p.R211P	ACH-000392	Lung Cancer	CCLE	FPLHSE	LIG_APCC_ABBA_1	0.0833
p.R211P	Calu-3	lung	COSMIC	FPLHSE	LIG_APCC_ABBA_1	0.0833
p.V210I	DO233867	GACA	ICGC	FPLHSE	LIG_APCC_ABBA_1	0.0556
p.V210F	DO229026	LICA	ICGC	FPLHSE	LIG_APCC_ABBA_1	0.0556
p.V210F	DO229034	LICA	ICGC	FPLHSE	LIG_APCC_ABBA_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6GPH4	XIAP-associated factor 1	LIG_APCC_ABBA_1	220:225	FPLHSE	APC,CDC20,FZR1	0.7671	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons