DegronMD

Uniprot ID: Q6GPH4

Source protein: XIAP-associated factor 1

Source gene: XAF1

Class: LIG_APCC_ABBAyCdc20_2

Location: 219:225

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.913

ASA_SCORE: 102.9

COIL: 0.8411

CONS_SCORE: 0.1923

DSS_SCORE: 0.6896

HELIX: 0.1281

FCONS_SCORE: 0.6379

RIG_SCORE: 0.6354

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S234G	TCGA-17-Z014	LUAD	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R233K	TCGA-AP-A1DV	UCEC	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R233K	DO43186	UCEC	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.H223Y	TCGA-EE-A182	SKCM	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H223Y	DO37814	SKCM	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.6118
p.A231T	TCGA-QB-A6FS	SKCM	TCGA	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A231T	DO48654	SKCM	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.V210I	DO233867	GACA	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V210F	DO229026	LICA	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V210F	DO229034	LICA	ICGC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R219I	SIDM01004	Chronic Myelogenous Leukemia	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	SIDM00544	Neuroblastoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	SIDM00057	Neuroblastoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	SIDM00552	Rhabdomyosarcoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	SIDM00235	Kidney Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	SIDM00997	Thyroid Gland Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	SIDM00609	Kidney Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-000189	Kidney Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-000250	Kidney Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-000607	Rhabdoid	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-000773	Lymphoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-000961	Endometrial/Uterine Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-000983	Leukemia	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-001184	Sarcoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-001306	Thyroid Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-001623	Brain Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-001651	Endometrial/Uterine Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R219I	ACH-001716	Neuroblastoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.8102
p.R211C	SIDM00072	Non-Cancerous	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R211C	ACH-000206	Lymphoma	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P212Q	SIDM01078	Small Cell Lung Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P212Q	ACH-000790	Lung Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P212Q	SHP-77	lung	COSMIC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R211P	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R211P	ACH-000392	Lung Cancer	CCLE	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R211P	Calu-3	lung	COSMIC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P230S	EFO-21	ovary	COSMIC	RFPLHSE	LIG_APCC_ABBAyCdc20_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RFPLHSE

Degron related mutations and impact score

Drug responses associated with XAF1 mutations

All proteins holding degron of RFPLHSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6GPH4	XIAP-associated factor 1	LIG_APCC_ABBAyCdc20_2	219:225	RFPLHSE	APC,CDC20,FZR1	0.913	More...