DegronMD - Q96QH2(PRAM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q359H	TCGA-AX-A2HD	UCEC	TCGA	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.2222
p.Q359H	DO42608	UCEC	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.2222
p.E325K	TCGA-D9-A6EC	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1944
p.E325K	DO50291	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1944
p.R350C	TCGA-FI-A2D5	UCEC	TCGA	LQPERRGPPR	SCF_FBXL2	346:355	Mutation altering degron motif	0.719
p.R350C	TCGA-L5-A43J	ESCA	TCGA	LQPERRGPPR	SCF_FBXL2	346:355	Mutation altering degron motif	0.719
p.R350C	TCGA-Z7-A8R6	BRCA	TCGA	LQPERRGPPR	SCF_FBXL2	346:355	Mutation altering degron motif	0.719
p.R350C	DO51231	BRCA	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation altering degron motif	0.719
p.R350C	DO41331	UCEC	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation altering degron motif	0.719
p.L341P	TCGA-G3-A25W	LIHC	TCGA	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.L341P	TCGA-G3-A25W	LIHC	TCGA	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.1944
p.L341P	DO22970	LIHC	ICGC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1389
p.L341P	DO22970	LIHC	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.1944
p.A364T	TCGA-G4-6309	COAD	TCGA	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.0833
p.A364T	DO7810	COAD	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.0833
p.A364T	ACH-000930	Breast Cancer	CCLE	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.0833
p.P322L	DO222364	BTCA	ICGC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.1111
p.E337K	DO222769	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.25
p.E337K	DO222769	COCA	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.0833
p.R351Q	DO233884	GACA	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation altering degron motif	0.7329
p.Q359K	DO228952	LICA	ICGC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.2222
p.P330L	DO222875	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation altering degron motif	0.7582
p.R350S	SIDM00484	Thyroid Gland Carcinoma	GDSC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation altering degron motif	0.6316
p.P336R	SIDM00517	Head and Neck Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.P336R	SIDM00517	Head and Neck Carcinoma	GDSC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.0556
p.P336R	ACH-002239	Head and Neck Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.P336R	ACH-002239	Head and Neck Cancer	CCLE	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.0556
p.P336R	H3118	upper aerodigestive tract	COSMIC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation rewiring degron network	0.2778
p.P336R	H3118	upper aerodigestive tract	COSMIC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.0556
p.S363R	SIDM01182	Bladder Carcinoma	GDSC	LQPERRGPPR	SCF_FBXL2	346:355	Mutation rewiring degron network	0.1111
p.K344T	SIDM00118	Colorectal Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation substituting flanking lysine	0.1667
p.K344T	ACH-001081	Colon/Colorectal Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation substituting flanking lysine	0.1667
p.K344T	HCC2998	large intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	330:334	Mutation substituting flanking lysine	0.1667

Kaplan plot for PRAM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRAM1

UniProt ID: Q96QH2

Entrez ID: 84106

Protein name: PML-RARA-regulated adapter molecule 1 (PRAM) (PRAM-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRAM1 in