DegronMD

Uniprot ID: Q96QH2

Source protein: PML-RARA-regulated adapter molecule 1

Source gene: PRAM1

Class: SCF_FBXL2

Location: 346:355

E3 ligase: FBXL2

DEGRON score: 0.9984

ASA_SCORE: 109.62

COIL: 0.9706

CONS_SCORE: 0.4653

DSS_SCORE: 0.7741

HELIX: 0.0149

FCONS_SCORE: 1.3536

RIG_SCORE: 0.5929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q359H	TCGA-AX-A2HD	UCEC	TCGA	LQPERRGPPR	SCF_FBXL2	0.2222
p.Q359H	DO42608	UCEC	ICGC	LQPERRGPPR	SCF_FBXL2	0.2222
p.R350C	TCGA-FI-A2D5	UCEC	TCGA	LQPERRGPPR	SCF_FBXL2	0.719
p.R350C	TCGA-L5-A43J	ESCA	TCGA	LQPERRGPPR	SCF_FBXL2	0.719
p.R350C	TCGA-Z7-A8R6	BRCA	TCGA	LQPERRGPPR	SCF_FBXL2	0.719
p.R350C	DO51231	BRCA	ICGC	LQPERRGPPR	SCF_FBXL2	0.719
p.R350C	DO41331	UCEC	ICGC	LQPERRGPPR	SCF_FBXL2	0.719
p.L341P	TCGA-G3-A25W	LIHC	TCGA	LQPERRGPPR	SCF_FBXL2	0.1944
p.L341P	DO22970	LIHC	ICGC	LQPERRGPPR	SCF_FBXL2	0.1944
p.A364T	TCGA-G4-6309	COAD	TCGA	LQPERRGPPR	SCF_FBXL2	0.0833
p.A364T	DO7810	COAD	ICGC	LQPERRGPPR	SCF_FBXL2	0.0833
p.A364T	ACH-000930	Breast Cancer	CCLE	LQPERRGPPR	SCF_FBXL2	0.0833
p.E337K	DO222769	COCA	ICGC	LQPERRGPPR	SCF_FBXL2	0.0833
p.R351Q	DO233884	GACA	ICGC	LQPERRGPPR	SCF_FBXL2	0.7329
p.Q359K	DO228952	LICA	ICGC	LQPERRGPPR	SCF_FBXL2	0.2222
p.R350S	SIDM00484	Thyroid Gland Carcinoma	GDSC	LQPERRGPPR	SCF_FBXL2	0.6316
p.P336R	SIDM00517	Head and Neck Carcinoma	GDSC	LQPERRGPPR	SCF_FBXL2	0.0556
p.P336R	ACH-002239	Head and Neck Cancer	CCLE	LQPERRGPPR	SCF_FBXL2	0.0556
p.P336R	H3118	upper_aerodigestive_tract	COSMIC	LQPERRGPPR	SCF_FBXL2	0.0556
p.S363R	SIDM01182	Bladder Carcinoma	GDSC	LQPERRGPPR	SCF_FBXL2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QH2	PML-RARA-regulated adapter molecule 1	SCF_FBXL2	346:355	LQPERRGPPR	FBXL2	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons