DegronMD - Q9ULC8(ZDHHC8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R452C	TCGA-06-5416	GBM	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1944
p.R452C	TCGA-A6-6654	COAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1944
p.R452C	TCGA-EY-A215	UCEC	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1944
p.P457A	TCGA-BR-8059	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	TCGA-BR-8591	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	TCGA-G4-6588	COAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	TCGA-VQ-A8PT	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	DO10140	COAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	DO45299	LIRI	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	DO38443	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	DO51776	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	DO47973	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	SIDM01612	Endometrial Carcinoma	GDSC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.P457A	ACH-000723	Head and Neck Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7503
p.E454K	TCGA-C8-A26Y	BRCA	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.25
p.E454K	DO1273	BRCA	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.25
p.F465S	TCGA-CQ-6221	HNSC	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.2778
p.P458L	TCGA-D3-A2JF	SKCM	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.6471
p.P458L	DO38153	SKCM	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.6471
p.S642P	TCGA-EO-A3B0	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.6752
p.S642P	DO219773	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.6752
p.S642L	TCGA-ER-A199	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.7667
p.A466V	TCGA-ET-A3DQ	THCA	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.25
p.R640Q	TCGA-HU-A4GQ	STAD	TCGA	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.6218
p.R640Q	DO47767	STAD	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.6218
p.Q449H	TCGA-HU-A4GU	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1111
p.Q449H	DO47849	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1111
p.Q449H	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1111
p.Q449H	ACH-001599	Lung Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1111
p.S645F	TCGA-Q9-A6FW	ESCA	TCGA	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation blocking phosphorylation signal	0.7222
p.A469S	TCGA-XF-A8HD	BLCA	TCGA	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1667
p.R448H	DO8103	COAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.0833
p.P641S	DO10582	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.6752
p.P641S	DO47368	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.6752
p.R640W	DO227855	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation altering degron motif	0.7523
p.G644S	DO10880	GBM	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.3056
p.P634L	DO52034	HNSC	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1944
p.P634L	SNU-1040	large intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1944
p.P652S	DO222521	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.0833
p.I460F	DO51960	PRAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation altering degron motif	0.7415
p.H468L	DO47100	RECA	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1944
p.P634S	DO37444	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1944
p.L646Q	DO229275	THCA	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.25
p.R471C	DO42673	UCEC	ICGC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1111
p.R638W	DO41331	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.3056
p.R638W	RKO	large intestine	COSMIC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.3056
p.S645Y	SIDM00499	Prostate Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation blocking phosphorylation signal	0.7222
p.S645Y	ACH-000956	Prostate Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation blocking phosphorylation signal	0.7222
p.A648V	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1944
p.A648V	ACH-002256	Leukemia	CCLE	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1944
p.A648V	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	639:643	Mutation rewiring degron network	0.1944
p.R473C	SIDM00176	Chondrosarcoma	GDSC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.0556
p.R473C	ACH-002094	Bone Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.0556
p.E454A	ACH-001369	Ovarian Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.25
p.E468K	MEL-JUSO	skin	COSMIC	PPTPHRS	DEG_SCF_FBW7_1	457:463	Mutation rewiring degron network	0.1944

Kaplan plot for ZDHHC8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZDHHC8

UniProt ID: Q9ULC8

Entrez ID: 29801

Protein name: Palmitoyltransferase ZDHHC8 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZDHHC8 in