DegronMD

Uniprot ID: Q9ULC8

Source protein: Palmitoyltransferase ZDHHC8

Source gene: ZDHHC8

Class: DEG_SCF_FBW7_1

Location: 457:463

E3 ligase: FBXW7

DEGRON score: 0.6344

ASA_SCORE: 86.8571

COIL: 0.9043

CONS_SCORE: 0.2515

DSS_SCORE: 0.674

HELIX: 0.0576

FCONS_SCORE: 0.9078

RIG_SCORE: 0.5864

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R452C	TCGA-06-5416	GBM	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.1944
p.R452C	TCGA-A6-6654	COAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.1944
p.R452C	TCGA-EY-A215	UCEC	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.1944
p.P457A	TCGA-BR-8059	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	TCGA-BR-8591	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	TCGA-G4-6588	COAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	TCGA-VQ-A8PT	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	DO10140	COAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	DO45299	LIRI	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	DO38443	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	DO51776	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	DO47973	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	SIDM01612	Endometrial Carcinoma	GDSC	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.P457A	ACH-000723	Head and Neck Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	0.7503
p.E454K	TCGA-C8-A26Y	BRCA	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.25
p.E454K	DO1273	BRCA	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.25
p.F465S	TCGA-CQ-6221	HNSC	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.2778
p.P458L	TCGA-D3-A2JF	SKCM	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.6471
p.P458L	DO38153	SKCM	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.6471
p.A466V	TCGA-ET-A3DQ	THCA	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.25
p.Q449H	TCGA-HU-A4GU	STAD	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.1111
p.Q449H	DO47849	STAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.1111
p.Q449H	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPTPHRS	DEG_SCF_FBW7_1	0.1111
p.Q449H	ACH-001599	Lung Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	0.1111
p.A469S	TCGA-XF-A8HD	BLCA	TCGA	PPTPHRS	DEG_SCF_FBW7_1	0.1667
p.R448H	DO8103	COAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.0833
p.I460F	DO51960	PRAD	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.7415
p.H468L	DO47100	RECA	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.1944
p.R471C	DO42673	UCEC	ICGC	PPTPHRS	DEG_SCF_FBW7_1	0.1111
p.R473C	SIDM00176	Chondrosarcoma	GDSC	PPTPHRS	DEG_SCF_FBW7_1	0.0556
p.R473C	ACH-002094	Bone Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	0.0556
p.E454A	ACH-001369	Ovarian Cancer	CCLE	PPTPHRS	DEG_SCF_FBW7_1	0.25
p.E468K	MEL-JUSO	skin	COSMIC	PPTPHRS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTPHRS

Degron related mutations and impact score

Drug responses associated with ZDHHC8 mutations

All proteins holding degron of PPTPHRS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULC8	Palmitoyltransferase ZDHHC8	DEG_SCF_FBW7_1	457:463	PPTPHRS	FBXW7	0.6344	More...