DegronMD - Q03111(MLLT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S310N	TCGA-2W-A8YY	CESC	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.6111
p.S310N	DO223732	CESC	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.6111
p.S315L	TCGA-90-A4EE	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.75
p.S315L	DO45513	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.75
p.S325L	TCGA-A6-2686	COAD	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.6389
p.S325L	DO7828	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.6389
p.A311V	TCGA-AJ-A3EL	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1944
p.A311V	DO41542	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1944
p.A425V	TCGA-AP-A059	UCEC	TCGA	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation rewiring degron network	0.2778
p.A425V	DO41361	UCEC	ICGC	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation rewiring degron network	0.2778
p.S325P	TCGA-AP-A1DK	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.6389
p.S325P	DO42033	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.6389
p.R317C	TCGA-B5-A11E	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.719
p.R317C	DO41644	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.719
p.R309W	TCGA-D3-A2JF	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.R309W	DO38153	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.P316H	TCGA-D3-A3C7	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7694
p.P316H	DO47569	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7694
p.P312Q	TCGA-EM-A22J	THCA	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2222
p.P312Q	DO39096	THCA	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2222
p.G307W	TCGA-FS-A1ZP	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.G307W	DO37703	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0833
p.K327N	TCGA-G7-6797	KIRP	TCGA	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation substituting flanking lysine	0.25
p.K327N	DO20917	KIRP	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation substituting flanking lysine	0.25
p.R309Q	DO227549	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.1389
p.E423K	DO234392	ESAD	ICGC	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation altering degron motif	0.7022
p.E423K	ACH-000774	Lung Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation altering degron motif	0.7022
p.G432W	DO48320	ESCA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation rewiring degron network	0.0833
p.T429N	DO229045	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation rewiring degron network	0.1667
p.S323F	DO229062	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation blocking phosphorylation signal	0.6944
p.P431Q	DO229008	LICA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation rewiring degron network	0.1111
p.R317H	DO228842	PBCA	ICGC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation altering degron motif	0.7133
p.S421L	DO229259	THCA	ICGC	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation altering degron motif	0.8778
p.A330S	SIDM00889	Cervical Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0556
p.A330S	C-33-A	cervix	COSMIC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.0556
p.S322F	SIDM01765	Osteosarcoma	GDSC	PRTSS	DEG_SPOP_SBC_1	316:320	Mutation rewiring degron network	0.2778
p.P431L	ACH-000972	Endometrial/Uterine Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation rewiring degron network	0.1111
p.D418N	ACH-000994	Endometrial/Uterine Cancer	CCLE	DSSSGE	DEG_Kelch_Keap1_1	418:423	Mutation altering degron motif	0.5821

Kaplan plot for MLLT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLLT1

UniProt ID: Q03111

Entrez ID: 4298

Protein name: Protein ENL (YEATS domain-containing protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLLT1 in