DegronMD - Q96K62(ZBTB45)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S131F	TCGA-05-4398	LUAD	TCGA	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2778
p.S131F	DO25847	LUAD	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2778
p.R160S	TCGA-60-2703	LUSC	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.25
p.R160S	DO27715	LUSC	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.25
p.G163W	TCGA-75-5146	LUAD	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.1667
p.G163W	DO25228	LUAD	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.1667
p.P401S	TCGA-A6-6780	COAD	TCGA	PPTY	ITCH	400:403	Mutation altering degron motif	0.6752
p.P401S	DO10244	COAD	ICGC	PPTY	ITCH	400:403	Mutation altering degron motif	0.6752
p.R154C	TCGA-BR-6852	STAD	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.719
p.R154C	DO38202	STAD	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.719
p.R154C	SIDM01113	Other Sarcomas	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.719
p.R154C	ACH-000939	Sarcoma	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.719
p.R154C	SK-UT-1	soft tissue	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.719
p.T402M	TCGA-CD-8536	STAD	TCGA	PPTY	ITCH	400:403	Mutation altering degron motif	0.7423
p.T402M	DO47827	STAD	ICGC	PPTY	ITCH	400:403	Mutation altering degron motif	0.7423
p.R150C	TCGA-DU-6392	LGG	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.8301
p.R150C	DO22237	LGG	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.8301
p.T411M	TCGA-ED-A97K	LIHC	TCGA	PPTY	ITCH	400:403	Mutation blocking phosphorylation signal	0.5556
p.T411M	DO49682	LIHC	ICGC	PPTY	ITCH	400:403	Mutation blocking phosphorylation signal	0.5556
p.R124H	TCGA-EI-6882	READ	TCGA	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.0833
p.R124H	DO36531	READ	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.0833
p.A167T	TCGA-EO-A22U	UCEC	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.0556
p.A167T	DO43755	UCEC	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.0556
p.A387P	TCGA-G4-6320	COAD	TCGA	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.3056
p.A387P	TCGA-G4-6320	COAD	TCGA	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1944
p.A387P	DO8159	COAD	ICGC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.3056
p.A387P	DO8159	COAD	ICGC	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1944
p.A387P	SIDM00500	Colorectal Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.3056
p.A387P	SIDM00500	Colorectal Carcinoma	GDSC	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1944
p.A387P	ACH-000959	Colon/Colorectal Cancer	CCLE	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.3056
p.A387P	ACH-000959	Colon/Colorectal Cancer	CCLE	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1944
p.E404Q	TCGA-G7-6790	KIRP	TCGA	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0833
p.E404Q	TCGA-G7-6790	KIRP	TCGA	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1944
p.E404Q	TCGA-G7-6790	KIRP	TCGA	PPTY	ITCH	400:403	Mutation rewiring degron network	0.3056
p.E404Q	DO20888	KIRP	ICGC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0833
p.E404Q	DO20888	KIRP	ICGC	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1944
p.E404Q	DO20888	KIRP	ICGC	PPTY	ITCH	400:403	Mutation rewiring degron network	0.3056
p.S406I	TCGA-HU-A4GU	STAD	TCGA	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1389
p.S406I	TCGA-HU-A4GU	STAD	TCGA	PPTY	ITCH	400:403	Mutation rewiring degron network	0.25
p.S406I	DO47849	STAD	ICGC	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1389
p.S406I	DO47849	STAD	ICGC	PPTY	ITCH	400:403	Mutation rewiring degron network	0.25
p.P392L	TCGA-IB-7651	PAAD	TCGA	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation altering degron motif	0.7582
p.P392L	TCGA-IB-7651	PAAD	TCGA	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation altering degron motif	0.6471
p.P392L	DO46657	PAAD	ICGC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation altering degron motif	0.7582
p.P392L	DO46657	PAAD	ICGC	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation altering degron motif	0.6471
p.R124C	DO224955	BRCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.0833
p.R150H	DO233885	GACA	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation altering degron motif	0.8244
p.T134K	DO229029	LICA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.8417
p.A127D	DO229009	LICA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1667
p.T138P	DO229163	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.7031
p.T138P	DO229199	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.7031
p.T138P	DO229089	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.7031
p.T138P	DO229088	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.7031
p.T138P	DO231286	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.7031
p.R126Q	SIDM01307	Colorectal Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1389
p.P142T	SIDM01951	Colorectal Carcinoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.1389
p.P142T	SIDM01951	Colorectal Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2222
p.P142L	SIDM00578	Neuroblastoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.1389
p.P142L	SIDM00578	Neuroblastoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2222
p.P142L	SIDM01779	Gastric Carcinoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.1389
p.P142L	SIDM01779	Gastric Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2222
p.P142L	NB1	autonomic ganglia	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.1389
p.P142L	NB1	autonomic ganglia	COSMIC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2222
p.P128L	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1944
p.P128L	ACH-002272	Lymphoma	CCLE	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1944
p.P128L	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1944
p.R394H	SIDM01090	Colorectal Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation altering degron motif	0.7133
p.R394H	SIDM01090	Colorectal Carcinoma	GDSC	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation altering degron motif	0.7133
p.A123T	SIDM00496	Thyroid Gland Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.0556
p.A123T	HTC-C3	thyroid	COSMIC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.0556
p.G390C	SIDM00789	Colorectal Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation altering degron motif	0.6489
p.G390C	ACH-000997	Colon/Colorectal Cancer	CCLE	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation altering degron motif	0.6489
p.G390C	ACH-001061	Colon/Colorectal Cancer	CCLE	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation altering degron motif	0.6489
p.G390C	HCT-15	large intestine	COSMIC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation altering degron motif	0.6489
p.C405S	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	388:395	Mutation rewiring degron network	0.0556
p.C405S	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PARTPGAE	DEG_SCF_FBW7_2	392:399	Mutation rewiring degron network	0.1667
p.C405S	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PPTY	ITCH	400:403	Mutation rewiring degron network	0.2778
p.A158D	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.3056
p.A158D	ACH-000920	Leukemia	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.3056
p.A158D	CML-T1	haematopoietic and lymphoid tissue	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.3056
p.V140M	SIDM00875	Breast Carcinoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.0833
p.V140M	SIDM00875	Breast Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2778
p.V140M	ACH-000624	Breast Cancer	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.0833
p.V140M	ACH-000624	Breast Cancer	CCLE	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2778
p.P161H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.2222
p.P161H	ACH-002222	Leukemia	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.2222
p.P161H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	149:157	Mutation rewiring degron network	0.2222
p.A132V	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.3056
p.A132V	Farage	haematopoietic and lymphoid tissue	COSMIC	PTPLPT	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZBTB45

UniProt ID: Q96K62

Entrez ID: 84878

Protein name: Zinc finger and BTB domain-containing protein 45 (Zinc finger protein 499)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZBTB45 in