DegronMD

Uniprot ID: Q96K62

Source protein: Zinc finger and BTB domain-containing protein 45

Source gene: ZBTB45

Class: DEG_SCF_FBW7_2

Location: 392:399

E3 ligase: FBXW7

DEGRON score: 0.8426

ASA_SCORE: 69.2375

COIL: 0.8494

CONS_SCORE: 0.5162

DSS_SCORE: 0.6349

HELIX: 0.0179

FCONS_SCORE: 0.8458

RIG_SCORE: 0.5716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A387P	TCGA-G4-6320	COAD	TCGA	PARTPGAE	DEG_SCF_FBW7_2	0.1944
p.A387P	DO8159	COAD	ICGC	PARTPGAE	DEG_SCF_FBW7_2	0.1944
p.A387P	SIDM00500	Colorectal Carcinoma	GDSC	PARTPGAE	DEG_SCF_FBW7_2	0.1944
p.A387P	ACH-000959	Colon/Colorectal Cancer	CCLE	PARTPGAE	DEG_SCF_FBW7_2	0.1944
p.E404Q	TCGA-G7-6790	KIRP	TCGA	PARTPGAE	DEG_SCF_FBW7_2	0.1944
p.E404Q	DO20888	KIRP	ICGC	PARTPGAE	DEG_SCF_FBW7_2	0.1944
p.S406I	TCGA-HU-A4GU	STAD	TCGA	PARTPGAE	DEG_SCF_FBW7_2	0.1389
p.S406I	DO47849	STAD	ICGC	PARTPGAE	DEG_SCF_FBW7_2	0.1389
p.P392L	TCGA-IB-7651	PAAD	TCGA	PARTPGAE	DEG_SCF_FBW7_2	0.6471
p.P392L	DO46657	PAAD	ICGC	PARTPGAE	DEG_SCF_FBW7_2	0.6471
p.R394H	SIDM01090	Colorectal Carcinoma	GDSC	PARTPGAE	DEG_SCF_FBW7_2	0.7133
p.C405S	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PARTPGAE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K62	Zinc finger and BTB domain-containing protein 45	DEG_SCF_FBW7_2	392:399	PARTPGAE	FBXW7	0.8426	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons