DegronMD

Uniprot ID: Q96K62

Source protein: Zinc finger and BTB domain-containing protein 45

Source gene: ZBTB45

Class: DEG_APCC_DBOX_1

Location: 149:157

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8124

ASA_SCORE: 109.4

COIL: 0.2824

CONS_SCORE: 0.6718

DSS_SCORE: 0.7033

HELIX: 0.7187

FCONS_SCORE: 1.2234

RIG_SCORE: 0.7161

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R160S	TCGA-60-2703	LUSC	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	0.25
p.R160S	DO27715	LUSC	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	0.25
p.G163W	TCGA-75-5146	LUAD	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	0.1667
p.G163W	DO25228	LUAD	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	0.1667
p.R154C	TCGA-BR-6852	STAD	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	0.719
p.R154C	DO38202	STAD	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	0.719
p.R154C	SIDM01113	Other Sarcomas	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	0.719
p.R154C	ACH-000939	Sarcoma	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	0.719
p.R154C	SK-UT-1	soft_tissue	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	0.719
p.R150C	TCGA-DU-6392	LGG	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	0.8301
p.R150C	DO22237	LGG	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	0.8301
p.A167T	TCGA-EO-A22U	UCEC	TCGA	LRHRLRHLL	DEG_APCC_DBOX_1	0.0556
p.A167T	DO43755	UCEC	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	0.0556
p.R150H	DO233885	GACA	ICGC	LRHRLRHLL	DEG_APCC_DBOX_1	0.8244
p.P142T	SIDM01951	Colorectal Carcinoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	0.1389
p.P142L	SIDM00578	Neuroblastoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	0.1389
p.P142L	SIDM01779	Gastric Carcinoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	0.1389
p.P142L	NB1	autonomic_ganglia	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	0.1389
p.A158D	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	0.3056
p.A158D	ACH-000920	Leukemia	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	0.3056
p.A158D	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	0.3056
p.V140M	SIDM00875	Breast Carcinoma	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	0.0833
p.V140M	ACH-000624	Breast Cancer	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	0.0833
p.P161H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	LRHRLRHLL	DEG_APCC_DBOX_1	0.2222
p.P161H	ACH-002222	Leukemia	CCLE	LRHRLRHLL	DEG_APCC_DBOX_1	0.2222
p.P161H	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRHRLRHLL	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRHRLRHLL

Degron related mutations and impact score

Drug responses associated with ZBTB45 mutations

All proteins holding degron of LRHRLRHLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K62	Zinc finger and BTB domain-containing protein 45	DEG_APCC_DBOX_1	149:157	LRHRLRHLL	APC,CDC20,FZR1	0.8124	More...