DegronMD

Uniprot ID: Q96K62

Source protein: Zinc finger and BTB domain-containing protein 45

Source gene: ZBTB45

Class: DEG_SCF_FBW7_1

Location: 388:395

E3 ligase: FBXW7

DEGRON score: 0.9048

ASA_SCORE: 73.2

COIL: 0.8626

CONS_SCORE: 0.4997

DSS_SCORE: 0.7123

HELIX: 0.0231

FCONS_SCORE: 0.8784

RIG_SCORE: 0.5494

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A387P	TCGA-G4-6320	COAD	TCGA	PSGTPART	DEG_SCF_FBW7_1	0.3056
p.A387P	DO8159	COAD	ICGC	PSGTPART	DEG_SCF_FBW7_1	0.3056
p.A387P	SIDM00500	Colorectal Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	0.3056
p.A387P	ACH-000959	Colon/Colorectal Cancer	CCLE	PSGTPART	DEG_SCF_FBW7_1	0.3056
p.E404Q	TCGA-G7-6790	KIRP	TCGA	PSGTPART	DEG_SCF_FBW7_1	0.0833
p.E404Q	DO20888	KIRP	ICGC	PSGTPART	DEG_SCF_FBW7_1	0.0833
p.P392L	TCGA-IB-7651	PAAD	TCGA	PSGTPART	DEG_SCF_FBW7_1	0.7582
p.P392L	DO46657	PAAD	ICGC	PSGTPART	DEG_SCF_FBW7_1	0.7582
p.R394H	SIDM01090	Colorectal Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	0.7133
p.G390C	SIDM00789	Colorectal Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	0.6489
p.G390C	ACH-000997	Colon/Colorectal Cancer	CCLE	PSGTPART	DEG_SCF_FBW7_1	0.6489
p.G390C	ACH-001061	Colon/Colorectal Cancer	CCLE	PSGTPART	DEG_SCF_FBW7_1	0.6489
p.G390C	HCT-15	large_intestine	COSMIC	PSGTPART	DEG_SCF_FBW7_1	0.6489
p.C405S	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	PSGTPART	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96K62	Zinc finger and BTB domain-containing protein 45	DEG_SCF_FBW7_1	388:395	PSGTPART	FBXW7	0.9048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons