DegronMD

Uniprot ID: Q96K62

Source protein: Zinc finger and BTB domain-containing protein 45

Source gene: ZBTB45

Class: DEG_SCF_FBW7_1

Location: 133:138

E3 ligase: FBXW7

DEGRON score: 0.9501

ASA_SCORE: 98.5

COIL: 0.9755

CONS_SCORE: 0.5337

DSS_SCORE: 0.6883

HELIX: 0.0087

FCONS_SCORE: 0.9421

RIG_SCORE: 0.6057

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S131F	TCGA-05-4398	LUAD	TCGA	PTPLPT	DEG_SCF_FBW7_1	0.2778
p.S131F	DO25847	LUAD	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.2778
p.R124H	TCGA-EI-6882	READ	TCGA	PTPLPT	DEG_SCF_FBW7_1	0.0833
p.R124H	DO36531	READ	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.0833
p.R124C	DO224955	BRCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.0833
p.T134K	DO229029	LICA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.8417
p.A127D	DO229009	LICA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.1667
p.T138P	DO229163	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.7031
p.T138P	DO229199	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.7031
p.T138P	DO229089	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.7031
p.T138P	DO229088	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.7031
p.T138P	DO231286	THCA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.7031
p.R126Q	SIDM01307	Colorectal Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.1389
p.P142T	SIDM01951	Colorectal Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.2222
p.P142L	SIDM00578	Neuroblastoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.2222
p.P142L	SIDM01779	Gastric Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.2222
p.P142L	NB1	autonomic_ganglia	COSMIC	PTPLPT	DEG_SCF_FBW7_1	0.2222
p.P128L	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.1944
p.P128L	ACH-002272	Lymphoma	CCLE	PTPLPT	DEG_SCF_FBW7_1	0.1944
p.P128L	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLPT	DEG_SCF_FBW7_1	0.1944
p.A123T	SIDM00496	Thyroid Gland Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.0556
p.A123T	HTC-C3	thyroid	COSMIC	PTPLPT	DEG_SCF_FBW7_1	0.0556
p.V140M	SIDM00875	Breast Carcinoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.2778
p.V140M	ACH-000624	Breast Cancer	CCLE	PTPLPT	DEG_SCF_FBW7_1	0.2778
p.A132V	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.3056
p.A132V	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	PTPLPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1088:1093	PTPLPT	FBXW7	0.9112	More...
Q96K62	Zinc finger and BTB domain-containing protein 45	DEG_SCF_FBW7_1	133:138	PTPLPT	FBXW7	0.9501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPLPT

Degron related mutations and impact score

Drug responses associated with ZBTB45 mutations

All proteins holding degron of PTPLPT