DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1088:1093

E3 ligase: FBXW7

DEGRON score: 0.9112

ASA_SCORE: 87.3333

COIL: 0.9565

CONS_SCORE: 0.4369

DSS_SCORE: 0.7364

HELIX: 0.016

FCONS_SCORE: 1.0355

RIG_SCORE: 0.6117

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1089S	DO233737	GACA	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.7116
p.P1095L	TCGA-XR-A8TD	LIHC	TCGA	PTPLPT	DEG_SCF_FBW7_1	0.2778
p.P1095L	DO223921	LIHC	ICGC	PTPLPT	DEG_SCF_FBW7_1	0.2778
p.S1103F	SIDM00713	Mesothelioma	GDSC	PTPLPT	DEG_SCF_FBW7_1	0.0556
p.S1103F	ACH-000153	Lung Cancer	CCLE	PTPLPT	DEG_SCF_FBW7_1	0.0556
p.S1103F	NCI-H2052	pleura	COSMIC	PTPLPT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1088:1093	PTPLPT	FBXW7	0.9112	More...
Q96K62	Zinc finger and BTB domain-containing protein 45	DEG_SCF_FBW7_1	133:138	PTPLPT	FBXW7	0.9501	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons