DegronMD - O75175(CNOT3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P271L	TCGA-66-2791	LUSC	TCGA	PTSTT	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1667
p.P271L	DO26435	LUSC	ICGC	PTSTT	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1667
p.R568Q	TCGA-68-A59J	LUSC	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.1944
p.R568Q	TCGA-AP-A0LM	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.1944
p.R568Q	TCGA-AP-A1E0	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.1944
p.S554P	TCGA-78-7148	LUAD	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation altering degron motif	0.6752
p.A515S	TCGA-85-8584	LUSC	TCGA	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.2778
p.A515S	DO45438	LUSC	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.2778
p.T562M	TCGA-A5-A0G2	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation altering degron motif	0.7423
p.T562M	DO41235	UCEC	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation altering degron motif	0.7423
p.P499S	TCGA-A6-2686	COAD	TCGA	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.0833
p.P499S	DO7828	COAD	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.0833
p.R549W	TCGA-AA-A022	COAD	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.A547V	TCGA-AX-A0J1	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.1667
p.A520V	TCGA-AX-A2HD	UCEC	TCGA	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1389
p.L565P	TCGA-B5-A11Y	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2778
p.P501H	TCGA-B5-A3FC	UCEC	TCGA	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1389
p.I571V	TCGA-BH-A18G	BRCA	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.1111
p.I571V	DO3686	BRCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.1111
p.T509M	TCGA-EA-A410	CESC	TCGA	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation altering degron motif	0.7423
p.P458S	TCGA-ER-A19W	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1389
p.E252K	TCGA-FD-A3SO	BLCA	TCGA	PTSTT	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.E252K	DO569	BLCA	ICGC	PTSTT	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0833
p.P261H	TCGA-FS-A1Z4	SKCM	TCGA	PTSTT	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7694
p.P261H	DO37462	SKCM	ICGC	PTSTT	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7694
p.P477T	TCGA-GN-A26C	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1111
p.A474V	TCGA-HU-A4GN	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1944
p.A474V	DO47833	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1944
p.A551V	TCGA-L5-A43J	ESCA	TCGA	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2778
p.G460S	TCGA-VQ-A91D	STAD	TCGA	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1944
p.G460S	DO51783	STAD	ICGC	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1944
p.P477S	TCGA-W3-AA21	SKCM	TCGA	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1111
p.A505G	DO508	BLCA	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.25
p.T328M	DO49929	CESC	ICGC	PPTY	ITCH	320:323	Mutation rewiring degron network	0.1944
p.S549L	DO227709	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.S549L	DO229010	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.S549L	DO229013	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.S549L	DO229005	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.S549L	DO229346	LAML	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.S549L	DO231114	LUSC	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.S549L	DO27813	MALY	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.L521M	DO227996	COCA	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1111
p.L514P	DO233072	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.3056
p.P520L	DO233088	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1389
p.S552F	DO233631	GACA	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.3056
p.S509I	DO233918	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation altering degron motif	0.7341
p.A519V	DO233905	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1667
p.Q312H	DO23316	LINC	ICGC	PPTY	ITCH	320:323	Mutation rewiring degron network	0.1111
p.E561D	DO220312	SARC	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation altering degron motif	0.6758
p.W506L	DO37515	SKCM	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation blocking phosphorylation signal	0.7222
p.W506L	DO47619	SKCM	ICGC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation blocking phosphorylation signal	0.7222
p.R459W	DO41638	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.1667
p.P320H	DO41871	UCEC	ICGC	PPTY	ITCH	320:323	Mutation altering degron motif	0.7694
p.P543L	DO43755	UCEC	ICGC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.0556
p.G326A	SIDM00683	Prostate Carcinoma	GDSC	PPTY	ITCH	320:323	Mutation rewiring degron network	0.25
p.G326A	ACH-000977	lymph node	CCLE	PPTY	ITCH	320:323	Mutation rewiring degron network	0.25
p.G519D	SIDM00799	Glioblastoma	GDSC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1667
p.G519D	ACH-000558	Brain Cancer	CCLE	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1667
p.G519D	A172	central nervous system	COSMIC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.1667
p.P504A	SIDM00282	Colorectal Carcinoma	GDSC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.2222
p.P504A	ACH-000998	Colon/Colorectal Cancer	CCLE	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.2222
p.P504A	CW-2	large intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	508:513	Mutation rewiring degron network	0.2222
p.P559L	SIDM01188	Pancreatic Carcinoma	GDSC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation altering degron motif	0.6471
p.P559L	ACH-000114	Pancreatic Cancer	CCLE	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation altering degron motif	0.6471
p.P559L	SU8686	pancreas	COSMIC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation altering degron motif	0.6471
p.R549Q	SIDM01525	Acute Myeloid Leukemia	GDSC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.R549Q	ACH-000557	Leukemia	CCLE	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.2222
p.T464M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPSTS	DEG_SPOP_SBC_1	465:469	Mutation rewiring degron network	0.3056
p.P323A	CW-2	large intestine	COSMIC	PPTY	ITCH	320:323	Mutation altering degron motif	0.7503
p.A550G	Calu-3	lung	COSMIC	SSGIEDPVPTL	DEG_COP1_1	553:563	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNOT3

UniProt ID: O75175

Entrez ID: 4849

Protein name: CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNOT3 in