DegronMD

Uniprot ID: O75175

Source protein: CCR4-NOT transcription complex subunit 3

Source gene: CNOT3

Class: DEG_SCF_FBW7_1

Location: 508:513

E3 ligase: FBXW7

DEGRON score: 0.9833

ASA_SCORE: 82.7

COIL: 0.8057

CONS_SCORE: 0.2594

DSS_SCORE: 0.5936

HELIX: 0.1732

FCONS_SCORE: 1.0057

RIG_SCORE: 0.6138

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A515S	TCGA-85-8584	LUSC	TCGA	PTPSFS	DEG_SCF_FBW7_1	0.2778
p.A515S	DO45438	LUSC	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.2778
p.P499S	TCGA-A6-2686	COAD	TCGA	PTPSFS	DEG_SCF_FBW7_1	0.0833
p.P499S	DO7828	COAD	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.0833
p.A520V	TCGA-AX-A2HD	UCEC	TCGA	PTPSFS	DEG_SCF_FBW7_1	0.1389
p.P501H	TCGA-B5-A3FC	UCEC	TCGA	PTPSFS	DEG_SCF_FBW7_1	0.1389
p.T509M	TCGA-EA-A410	CESC	TCGA	PTPSFS	DEG_SCF_FBW7_1	0.7423
p.A505G	DO508	BLCA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.25
p.L521M	DO227996	COCA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.1111
p.L514P	DO233072	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.3056
p.P520L	DO233088	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.1389
p.S509I	DO233918	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.7341
p.A519V	DO233905	GACA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.1667
p.W506L	DO37515	SKCM	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.7222
p.W506L	DO47619	SKCM	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.7222
p.G519D	SIDM00799	Glioblastoma	GDSC	PTPSFS	DEG_SCF_FBW7_1	0.1667
p.G519D	ACH-000558	Brain Cancer	CCLE	PTPSFS	DEG_SCF_FBW7_1	0.1667
p.G519D	A172	central_nervous_system	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.1667
p.P504A	SIDM00282	Colorectal Carcinoma	GDSC	PTPSFS	DEG_SCF_FBW7_1	0.2222
p.P504A	ACH-000998	Colon/Colorectal Cancer	CCLE	PTPSFS	DEG_SCF_FBW7_1	0.2222
p.P504A	CW-2	large_intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SCF_FBW7_1	508:513	PTPSFS	FBXW7	0.9833	More...
Q8IVT5	Kinase suppressor of Ras 1	DEG_SCF_FBW7_1	239:244	PTPSFS	FBXW7	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons