DegronMD

Uniprot ID: Q8IVT5

Source protein: Kinase suppressor of Ras 1

Source gene: KSR1

Class: DEG_SCF_FBW7_1

Location: 239:244

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 74.25

COIL: 0.8935

CONS_SCORE: 0.3228

DSS_SCORE: 0.5454

HELIX: 0.0418

FCONS_SCORE: 0.904

RIG_SCORE: 0.6048

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A251V	TCGA-2W-A8YY	CESC	TCGA	PTPSFS	DEG_SCF_FBW7_1	0.1389
p.E250D	TCGA-EE-A3JI	SKCM	TCGA	PTPSFS	DEG_SCF_FBW7_1	0.6111
p.S231P	DO227657	COCA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.1111
p.S231P	DO46657	PAAD	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.1111
p.T240P	DO231101	LAML	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.8142
p.A235S	DO228985	LICA	ICGC	PTPSFS	DEG_SCF_FBW7_1	0.2222
p.A253T	SIDM01169	Ovarian Carcinoma	GDSC	PTPSFS	DEG_SCF_FBW7_1	0.0833
p.A253T	ACH-000885	Ovarian Cancer	CCLE	PTPSFS	DEG_SCF_FBW7_1	0.0833
p.A253T	TOV-21G	ovary	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.0833
p.R254Q	HSC-39	stomach	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.0556
p.A235T	SNU-1040	large_intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.2222
p.T240A	MZ7-mel	skin	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.825
p.S229P	GP5d	large_intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.5
p.S237P	GP5d	large_intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.2778
p.R231Q	786-0	kidney	COSMIC	PTPSFS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_SCF_FBW7_1	508:513	PTPSFS	FBXW7	0.9833	More...
Q8IVT5	Kinase suppressor of Ras 1	DEG_SCF_FBW7_1	239:244	PTPSFS	FBXW7	0.9911	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons