DegronMD - Q8IVT5(KSR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R266S	TCGA-17-Z018	LUAD	TCGA	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.25
p.A251V	TCGA-2W-A8YY	CESC	TCGA	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.1389
p.R280K	TCGA-4Z-AA84	BLCA	TCGA	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1667
p.R280K	DO218988	BLCA	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1667
p.G453C	TCGA-77-A5G6	LUSC	TCGA	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation rewiring degron network	0.3056
p.G453C	DO50097	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation rewiring degron network	0.3056
p.A281E	TCGA-86-8674	LUAD	TCGA	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1389
p.A281T	TCGA-AA-3492	COAD	TCGA	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1389
p.A281T	DO8224	COAD	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1389
p.R265W	TCGA-AJ-A3EK	UCEC	TCGA	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.2222
p.R265W	DO41584	UCEC	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.2222
p.R265W	SIDM01169	Ovarian Carcinoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.2222
p.R265W	ACH-000885	Ovarian Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.2222
p.R265W	TOV-21G	ovary	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.2222
p.E283K	TCGA-AN-A046	BRCA	TCGA	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.0833
p.R457C	TCGA-EE-A29M	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation rewiring degron network	0.1944
p.E250D	TCGA-EE-A3JI	SKCM	TCGA	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation blocking phosphorylation signal	0.6111
p.D273V	TCGA-KD-A5QS	SARC	TCGA	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.7785
p.R452W	DO223490	CLLE	ICGC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation altering degron motif	0.8634
p.R259W	DO230323	COCA	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.0556
p.S231P	DO227657	COCA	ICGC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.1111
p.S231P	DO46657	PAAD	ICGC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.1111
p.R449W	DO227973	COCA	ICGC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation altering degron motif	0.8634
p.T240P	DO231101	LAML	ICGC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.8142
p.A235S	DO228985	LICA	ICGC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.2222
p.P448T	DO23470	LINC	ICGC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation altering degron motif	0.7031
p.R263P	DO228338	MALY	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1667
p.R263P	DG-75	haematopoietic and lymphoid tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1667
p.R263C	DO219501	SKCM	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1667
p.R263C	SUP-M2	haematopoietic and lymphoid tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1667
p.T274P	DO229221	THCA	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.8142
p.R278Q	DO43714	UCEC	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.2222
p.R278Q	H4	central nervous system	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.2222
p.L283V	DO41193	UCEC	ICGC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.0833
p.A253T	SIDM01169	Ovarian Carcinoma	GDSC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.A253T	ACH-000885	Ovarian Cancer	CCLE	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.A253T	TOV-21G	ovary	COSMIC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.S272L	SIDM00588	Oral Cavity Carcinoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.7667
p.S272L	SIDM00845	Burkitt's Lymphoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.7667
p.S272L	HSC-4	upper aerodigestive tract	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.7667
p.S272L	Daudi	haematopoietic and lymphoid tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.7667
p.S269Y	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.712
p.S269Y	ACH-000980	Lung Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.712
p.S269Y	NCI-H1155	lung	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.712
p.R448H	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation altering degron motif	0.8244
p.R448H	ACH-002222	Leukemia	CCLE	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation altering degron motif	0.8244
p.R448H	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation altering degron motif	0.8244
p.T270P	ACH-000905	Bladder Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.8142
p.S269F	ACH-001566	Skin Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.7982
p.R254Q	HSC-39	stomach	COSMIC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0556
p.A235T	SNU-1040	large intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.2222
p.H263R	SNU-175	large intestine	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1667
p.T270M	YKG-1	central nervous system	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.8534
p.T240A	MZ7-mel	skin	COSMIC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.825
p.S266P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.25
p.S229P	GP5d	large intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation blocking phosphorylation signal	0.5
p.R262Q	HSC-39	stomach	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1389
p.H271R	SNU-175	large intestine	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.8244
p.A438V	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation rewiring degron network	0.0556
p.T262M	YKG-1	central nervous system	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.1389
p.P271L	Hs633T	soft tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.7582
p.H441R	HEC-1	endometrium	COSMIC	PSSTT	DEG_SPOP_SBC_1	448:452	Mutation rewiring degron network	0.1389
p.S237P	GP5d	large intestine	COSMIC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.2778
p.S274P	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation altering degron motif	0.6752
p.G266R	22RV1	prostate	COSMIC	ITPPTT	DEG_SCF_FBW7_1	269:274	Mutation rewiring degron network	0.25
p.R231Q	786-0	kidney	COSMIC	PTPSFS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.1111

Kaplan plot for KSR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KSR1

UniProt ID: Q8IVT5

Entrez ID: 8844

Protein name: Kinase suppressor of Ras 1 (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KSR1 in