DegronMD

Uniprot ID: Q8IVT5

Source protein: Kinase suppressor of Ras 1

Source gene: KSR1

Class: DEG_SCF_FBW7_1

Location: 269:274

E3 ligase: FBXW7

DEGRON score: 0.9962

ASA_SCORE: 94.4667

COIL: 0.9798

CONS_SCORE: 0.3835

DSS_SCORE: 0.6649

HELIX: 0.0067

FCONS_SCORE: 1.0561

RIG_SCORE: 0.6547

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R266S	TCGA-17-Z018	LUAD	TCGA	ITPPTT	DEG_SCF_FBW7_1	0.25
p.R280K	TCGA-4Z-AA84	BLCA	TCGA	ITPPTT	DEG_SCF_FBW7_1	0.1667
p.R280K	DO218988	BLCA	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.1667
p.A281E	TCGA-86-8674	LUAD	TCGA	ITPPTT	DEG_SCF_FBW7_1	0.1389
p.A281T	TCGA-AA-3492	COAD	TCGA	ITPPTT	DEG_SCF_FBW7_1	0.1389
p.A281T	DO8224	COAD	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.1389
p.R265W	TCGA-AJ-A3EK	UCEC	TCGA	ITPPTT	DEG_SCF_FBW7_1	0.2222
p.R265W	DO41584	UCEC	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.2222
p.R265W	SIDM01169	Ovarian Carcinoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	0.2222
p.R265W	ACH-000885	Ovarian Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	0.2222
p.R265W	TOV-21G	ovary	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.2222
p.E283K	TCGA-AN-A046	BRCA	TCGA	ITPPTT	DEG_SCF_FBW7_1	0.0833
p.D273V	TCGA-KD-A5QS	SARC	TCGA	ITPPTT	DEG_SCF_FBW7_1	0.7785
p.R259W	DO230323	COCA	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.0556
p.R263P	DO228338	MALY	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.1667
p.R263P	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.1667
p.R263C	DO219501	SKCM	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.1667
p.R263C	SUP-M2	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.1667
p.T274P	DO229221	THCA	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.8142
p.R278Q	DO43714	UCEC	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.2222
p.R278Q	H4	central_nervous_system	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.2222
p.L283V	DO41193	UCEC	ICGC	ITPPTT	DEG_SCF_FBW7_1	0.0833
p.S272L	SIDM00588	Oral Cavity Carcinoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	0.7667
p.S272L	SIDM00845	Burkitt's Lymphoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	0.7667
p.S272L	HSC-4	upper_aerodigestive_tract	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.7667
p.S272L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.7667
p.S269Y	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	ITPPTT	DEG_SCF_FBW7_1	0.712
p.S269Y	ACH-000980	Lung Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	0.712
p.S269Y	NCI-H1155	lung	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.712
p.T270P	ACH-000905	Bladder Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	0.8142
p.S269F	ACH-001566	Skin Cancer	CCLE	ITPPTT	DEG_SCF_FBW7_1	0.7982
p.H263R	SNU-175	large_intestine	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.1667
p.T270M	YKG-1	central_nervous_system	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.8534
p.S266P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.25
p.R262Q	HSC-39	stomach	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.1389
p.H271R	SNU-175	large_intestine	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.8244
p.T262M	YKG-1	central_nervous_system	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.1389
p.P271L	Hs633T	soft_tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.7582
p.S274P	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.6752
p.G266R	22RV1	prostate	COSMIC	ITPPTT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ITPPTT

Degron related mutations and impact score

Drug responses associated with KSR1 mutations

All proteins holding degron of ITPPTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IVT5	Kinase suppressor of Ras 1	DEG_SCF_FBW7_1	269:274	ITPPTT	FBXW7	0.9962	More...