DegronMD

Uniprot ID: O75175

Source protein: CCR4-NOT transcription complex subunit 3

Source gene: CNOT3

Class: DEG_COP1_1

Location: 553:563

E3 ligase: COP1

DEGRON score: 0.9949

ASA_SCORE: 80.0818

COIL: 0.8499

CONS_SCORE: 0.256

DSS_SCORE: 0.4555

HELIX: 0.1088

FCONS_SCORE: 1.1198

RIG_SCORE: 0.6822

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R568Q	TCGA-68-A59J	LUSC	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.1944
p.R568Q	TCGA-AP-A0LM	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.1944
p.R568Q	TCGA-AP-A1E0	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.1944
p.S554P	TCGA-78-7148	LUAD	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.6752
p.T562M	TCGA-A5-A0G2	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.7423
p.T562M	DO41235	UCEC	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.7423
p.R549W	TCGA-AA-A022	COAD	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.A547V	TCGA-AX-A0J1	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.1667
p.L565P	TCGA-B5-A11Y	UCEC	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.2778
p.I571V	TCGA-BH-A18G	BRCA	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.1111
p.I571V	DO3686	BRCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.1111
p.A551V	TCGA-L5-A43J	ESCA	TCGA	SSGIEDPVPTL	DEG_COP1_1	0.2778
p.S549L	DO227709	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.S549L	DO229010	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.S549L	DO229013	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.S549L	DO229005	COCA	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.S549L	DO229346	LAML	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.S549L	DO231114	LUSC	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.S549L	DO27813	MALY	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.S552F	DO233631	GACA	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.3056
p.E561D	DO220312	SARC	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.6758
p.P543L	DO43755	UCEC	ICGC	SSGIEDPVPTL	DEG_COP1_1	0.0556
p.P559L	SIDM01188	Pancreatic Carcinoma	GDSC	SSGIEDPVPTL	DEG_COP1_1	0.6471
p.P559L	ACH-000114	Pancreatic Cancer	CCLE	SSGIEDPVPTL	DEG_COP1_1	0.6471
p.P559L	SU8686	pancreas	COSMIC	SSGIEDPVPTL	DEG_COP1_1	0.6471
p.R549Q	SIDM01525	Acute Myeloid Leukemia	GDSC	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.R549Q	ACH-000557	Leukemia	CCLE	SSGIEDPVPTL	DEG_COP1_1	0.2222
p.A550G	Calu-3	lung	COSMIC	SSGIEDPVPTL	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75175	CCR4-NOT transcription complex subunit 3	DEG_COP1_1	553:563	SSGIEDPVPTL	COP1	0.9949	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSGIEDPVPTL

Degron related mutations and impact score

Drug responses associated with CNOT3 mutations

All proteins holding degron of SSGIEDPVPTL