DegronMD - O75909(CCNK)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L471M	TCGA-F5-6814	READ	TCGA	PPAY	ITCH	462:465	Mutation rewiring degron network	0.1667
p.L471M	DO36556	READ	ICGC	PPAY	ITCH	462:465	Mutation rewiring degron network	0.1667
p.E454D	TCGA-RD-A7BW	STAD	TCGA	PPAY	ITCH	462:465	Mutation rewiring degron network	0.1111
p.E454D	DO48612	STAD	ICGC	PPAY	ITCH	462:465	Mutation rewiring degron network	0.1111
p.T13S	TCGA-SN-A6IS	TGCT	TCGA	MKENK	DEG_APCC_KENBOX_2	1:5	Mutation rewiring degron network	0.1111
p.S11L	DO227535	BRCA	ICGC	MKENK	DEG_APCC_KENBOX_2	1:5	Mutation rewiring degron network	0.1667
p.E454K	DO233178	GACA	ICGC	PPAY	ITCH	462:465	Mutation rewiring degron network	0.1111
p.K2N	DO233903	GACA	ICGC	MKENK	DEG_APCC_KENBOX_2	1:5	Mutation altering degron motif	0.6918
p.M579I	DO229015	LICA	ICGC	WMR	DEG_APCC_TPR_1	578:580	Mutation altering degron motif	0.6507
p.R523C	DO49418	PACA	ICGC	PPTY	ITCH	510:513	Mutation rewiring degron network	0.0556
p.H474R	DO229268	THCA	ICGC	PPAY	ITCH	462:465	Mutation rewiring degron network	0.0833
p.S8L	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	MKENK	DEG_APCC_KENBOX_2	1:5	Mutation rewiring degron network	0.25
p.S8L	ACH-002214	Lymphoma	CCLE	MKENK	DEG_APCC_KENBOX_2	1:5	Mutation rewiring degron network	0.25
p.S8L	BC-1	haematopoietic and lymphoid tissue	COSMIC	MKENK	DEG_APCC_KENBOX_2	1:5	Mutation rewiring degron network	0.25
p.G571A	SIDM00930	Osteosarcoma	GDSC	WMR	DEG_APCC_TPR_1	578:580	Mutation rewiring degron network	0.1389
p.G455R	SIDM00784	Glioma	GDSC	PPAY	ITCH	462:465	Mutation rewiring degron network	0.1389
p.G455R	ACH-000126	Brain Cancer	CCLE	PPAY	ITCH	462:465	Mutation rewiring degron network	0.1389
p.A469V	ACH-000971	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	462:465	Mutation rewiring degron network	0.2222

Kaplan plot for CCNK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCNK

UniProt ID: O75909

Entrez ID: 8812

Protein name: Cyclin-K

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCNK in