DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
WMR
Uniprot ID:
O75909
Source protein:
Cyclin-K
Source gene:
CCNK
Class:
DEG_APCC_TPR_1
Location:
578:580
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9262
ASA_SCORE:
151.0333
COIL:
0.7053
CONS_SCORE:
0.3082
DSS_SCORE:
0.8986
HELIX:
0.275
FCONS_SCORE:
0.9905
RIG_SCORE:
0.7786
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M579I
DO229015
LICA
ICGC
WMR
DEG_APCC_TPR_1
0.6507
p.G571A
SIDM00930
Osteosarcoma
GDSC
WMR
DEG_APCC_TPR_1
0.1389
Drug responses associated with CCNK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of WMR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75909
Cyclin-K
DEG_APCC_TPR_1
578:580
WMR
APC,CDC20,FZR1
0.9262
More...