DegronMD

Uniprot ID: O75909

Source protein: Cyclin-K

Source gene: CCNK

Class: DEG_APCC_KENBOX_2

Location: 1:5

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8728

ASA_SCORE: 146.36

COIL: 0.9376

CONS_SCORE: 0.3358

DSS_SCORE: 0.9168

HELIX: 0.0548

FCONS_SCORE: 1.22

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T13S	TCGA-SN-A6IS	TGCT	TCGA	MKENK	DEG_APCC_KENBOX_2	0.1111
p.S11L	DO227535	BRCA	ICGC	MKENK	DEG_APCC_KENBOX_2	0.1667
p.K2N	DO233903	GACA	ICGC	MKENK	DEG_APCC_KENBOX_2	0.6918
p.S8L	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	MKENK	DEG_APCC_KENBOX_2	0.25
p.S8L	ACH-002214	Lymphoma	CCLE	MKENK	DEG_APCC_KENBOX_2	0.25
p.S8L	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	MKENK	DEG_APCC_KENBOX_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons