DegronMD

Uniprot ID: Q06520

Source protein: Sulfotransferase 2A1

Source gene: SULT2A1

Class: DEG_APCC_KENBOX_2

Location: 223:227

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7818

ASA_SCORE: 81.8

COIL: 0.5308

CONS_SCORE: 0.5145

DSS_SCORE: 0.2287

HELIX: 0.452

FCONS_SCORE: 1.2179

RIG_SCORE: 0.741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M228I	TCGA-55-A490	LUAD	TCGA	MKENK	DEG_APCC_KENBOX_2	0.3056
p.M228I	DO24596	LUAD	ICGC	MKENK	DEG_APCC_KENBOX_2	0.3056
p.L215I	TCGA-EO-A22X	UCEC	TCGA	MKENK	DEG_APCC_KENBOX_2	0.1111
p.L215I	DO229028	LICA	ICGC	MKENK	DEG_APCC_KENBOX_2	0.1111
p.L215I	DO43907	UCEC	ICGC	MKENK	DEG_APCC_KENBOX_2	0.1111
p.N217S	TCGA-ND-A4WC	UCS	TCGA	MKENK	DEG_APCC_KENBOX_2	0.1667
p.K224E	TCGA-XF-AAN0	BLCA	TCGA	MKENK	DEG_APCC_KENBOX_2	0.7022
p.K224E	DO51941	BLCA	ICGC	MKENK	DEG_APCC_KENBOX_2	0.7022
p.V236A	DO6519	CLLE	ICGC	MKENK	DEG_APCC_KENBOX_2	0.0833
p.S232Y	DO50755	LICA	ICGC	MKENK	DEG_APCC_KENBOX_2	0.1944
p.N230I	SIDM00107	Melanoma	GDSC	MKENK	DEG_APCC_KENBOX_2	0.25
p.N230I	SIDM01520	Oral Cavity Carcinoma	GDSC	MKENK	DEG_APCC_KENBOX_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons