DegronMD

Uniprot ID: P25391

Source protein: Laminin subunit alpha-1

Source gene: LAMA1

Class: LIG_APCC_ABBA_1

Location: 386:391

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7137

ASA_SCORE: 91.0167

COIL: 0.9455

CONS_SCORE: 0.3626

DSS_SCORE: 0.1012

HELIX: 0.042

FCONS_SCORE: 0.6778

RIG_SCORE: 0.7484

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R382T	TCGA-AG-A036	READ	TCGA	VSPYED	LIG_APCC_ABBA_1	0.2222
p.R382T	DO37245	READ	ICGC	VSPYED	LIG_APCC_ABBA_1	0.2222
p.K385N	TCGA-BR-7197	STAD	TCGA	VSPYED	LIG_APCC_ABBA_1	0.3056
p.K385N	DO38839	STAD	ICGC	VSPYED	LIG_APCC_ABBA_1	0.3056
p.D400N	TCGA-DX-AB2E	SARC	TCGA	VSPYED	LIG_APCC_ABBA_1	0.0833
p.D400N	DO220073	SARC	ICGC	VSPYED	LIG_APCC_ABBA_1	0.0833
p.Y380H	TCGA-HU-A4H3	STAD	TCGA	VSPYED	LIG_APCC_ABBA_1	0.1667
p.Y380H	DO47903	STAD	ICGC	VSPYED	LIG_APCC_ABBA_1	0.1667
p.R395C	DO234261	ESAD	ICGC	VSPYED	LIG_APCC_ABBA_1	0.2222
p.D378E	DO231515	LINC	ICGC	VSPYED	LIG_APCC_ABBA_1	0.1111
p.C399F	DO23186	LINC	ICGC	VSPYED	LIG_APCC_ABBA_1	0.1111
p.P388S	DO37782	SKCM	ICGC	VSPYED	LIG_APCC_ABBA_1	0.6752
p.P401S	SIDM01314	Colorectal Carcinoma	GDSC	VSPYED	LIG_APCC_ABBA_1	0.0556
p.P388T	SIDM00672	Hepatocellular Carcinoma	GDSC	VSPYED	LIG_APCC_ABBA_1	0.7031
p.P388T	ACH-000625	Liver Cancer	CCLE	VSPYED	LIG_APCC_ABBA_1	0.7031
p.P388T	Hep_3B2_1-7	NS	COSMIC	VSPYED	LIG_APCC_ABBA_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25391	Laminin subunit alpha-1	LIG_APCC_ABBA_1	386:391	VSPYED	APC,CDC20,FZR1	0.7137	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons