DegronMD

Uniprot ID: Q92859

Source protein: Neogenin

Source gene: NEO1

Class: DEG_COP1_1

Location: 730:741

E3 ligase: COP1

DEGRON score: 0.7517

ASA_SCORE: 84.0167

COIL: 0.8563

CONS_SCORE: 0.5923

DSS_SCORE: 0.4166

HELIX: 0.099

FCONS_SCORE: 1.0855

RIG_SCORE: 0.7682

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L733I	TCGA-18-3416	LUSC	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.6063
p.L733I	DO26423	LUSC	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.6063
p.V747L	TCGA-50-5933	LUAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.1667
p.V747L	DO24800	LUAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.1667
p.R737C	TCGA-A5-A1OF	UCEC	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.719
p.R737C	DO42568	UCEC	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.719
p.R748H	TCGA-A5-A1OF	UCEC	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.1389
p.R748H	DO42568	UCEC	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.1389
p.R737H	TCGA-AA-3713	COAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.7133
p.R737H	DO8400	COAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.7133
p.V751I	TCGA-BR-8380	STAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.0556
p.V751I	DO47803	STAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.0556
p.L745F	TCGA-EB-A41A	SKCM	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.2222
p.L745F	DO37429	SKCM	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.2222
p.S744C	TCGA-MN-A4N4	LUAD	TCGA	ESDLDETRVPEV	DEG_COP1_1	0.25
p.S744C	DO26250	LUAD	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.25
p.R748C	DO233261	GACA	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.1389
p.R748C	DO229257	THCA	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.1389
p.R737S	DO229272	THCA	ICGC	ESDLDETRVPEV	DEG_COP1_1	0.6316
p.V738A	SIDM00217	Colorectal Carcinoma	GDSC	ESDLDETRVPEV	DEG_COP1_1	0.6936
p.V738A	ACH-000999	Colon/Colorectal Cancer	CCLE	ESDLDETRVPEV	DEG_COP1_1	0.6936
p.V738A	SNU-1040	large_intestine	COSMIC	ESDLDETRVPEV	DEG_COP1_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92859	Neogenin	DEG_COP1_1	730:741	ESDLDETRVPEV	COP1	0.7517	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons