DegronMD - Q07912(TNK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A906P	TCGA-49-AAR9	LUAD	TCGA	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.7503
p.P634L	TCGA-75-6214	LUAD	TCGA	PPAY	ITCH	632:635	Mutation altering degron motif	0.7582
p.P914S	TCGA-78-8640	LUAD	TCGA	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.2778
p.A906T	TCGA-CK-4951	COAD	TCGA	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.7139
p.Q909K	TCGA-EE-A2GI	SKCM	TCGA	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.6944
p.P920L	TCGA-QG-A5YX	COAD	TCGA	APTATVRPM	DEG_SIAH_1	904:912	Mutation substituting flanking lysine	0.2222
p.D644N	DO51894	BLCA	ICGC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.0833
p.R642L	DO494	BLCA	ICGC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.1389
p.A921T	DO44166	BRCA	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.0833
p.A921D	DO44166	BRCA	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.0833
p.R610Q	DO223732	CESC	ICGC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.25
p.D601N	DO52443	COCA	ICGC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.5821
p.T899P	DO227410	EOPC	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.1944
p.T635N	DO50387	ESAD	ICGC	PPAY	ITCH	632:635	Mutation altering degron motif	0.7055
p.R627C	DO233833	GACA	ICGC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.1944
p.Q606E	DO14566	HNSC	ICGC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.5633
p.P631A	DO15366	HNSC	ICGC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.3056
p.Q592K	DO229015	LICA	ICGC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.1111
p.D636E	DO229015	LICA	ICGC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.3056
p.A634S	DO50898	LICA	ICGC	PPAY	ITCH	632:635	Mutation altering degron motif	0.6477
p.L600M	DO23210	LINC	ICGC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.5999
p.P895S	DO23590	LUAD	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.0833
p.A921S	DO26504	LUSC	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.0833
p.P615L	DO50299	SKCM	ICGC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.1111
p.K920R	DO50291	SKCM	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation substituting flanking lysine	0.2222
p.P905L	DO51301	SKCM	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.7582
p.P632L	DO48547	STAD	ICGC	PPAY	ITCH	632:635	Mutation altering degron motif	0.7582
p.A901V	DO47873	STAD	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.25
p.A596T	DO47773	STAD	ICGC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.2222
p.K920T	DO43755	UCEC	ICGC	APTATVRPM	DEG_SIAH_1	904:912	Mutation substituting flanking lysine	0.2222
p.R627H	DO42673	UCEC	ICGC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.1944
p.R632W	SIDM00596	Endometrial Carcinoma	GDSC	PPAY	ITCH	632:635	Mutation altering degron motif	0.8634
p.S600I	SIDM00511	Small Cell Lung Carcinoma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.7341
p.S600I	SIDM00887	Other Solid Cancers	GDSC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.7341
p.A644P	SIDM00849	Kidney Carcinoma	GDSC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.0833
p.R622Q	SIDM00276	Biliary Tract Carcinoma	GDSC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.0556
p.R622Q	SIDM01434	Hepatocellular Carcinoma	GDSC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.0556
p.R622Q	ETK-1	biliary tract	COSMIC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.0556
p.R616W	SIDM00379	Glioma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.0833
p.R616W	SIDM01001	Breast Carcinoma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.0833
p.R917W	SIDM00217	Colorectal Carcinoma	GDSC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.1944
p.R917W	SNU-1040	large intestine	COSMIC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.1944
p.D604V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.7785
p.T907N	SIDM00976	Melanoma	GDSC	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.7055
p.P605L	SIDM01318	Hepatocellular Carcinoma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.6471
p.G643R	SIDM01316	Ewing's Sarcoma	GDSC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.1111
p.P634S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	632:635	Mutation altering degron motif	0.6752
p.E602K	ACH-000293	Endometrial/Uterine Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.591
p.M594V	ACH-000323	Brain Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.1667
p.Y635C	ACH-000820	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	632:635	Mutation altering degron motif	0.8198
p.Y635C	SW403	large intestine	COSMIC	PPAY	ITCH	632:635	Mutation altering degron motif	0.8198
p.A590V	ACH-000972	Endometrial/Uterine Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.0556
p.A590V	ACH-000989	Colon/Colorectal Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.0556
p.R910Q	ACH-000994	Endometrial/Uterine Cancer	CCLE	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.6218
p.D595G	ACH-001208	Kidney Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.1944
p.D595G	TK10	kidney	COSMIC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation rewiring degron network	0.1944
p.R909C	SNU-283	large intestine	COSMIC	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.8301
p.R909C	Jurkat	haematopoietic and lymphoid tissue	COSMIC	APTATVRPM	DEG_SIAH_1	904:912	Mutation altering degron motif	0.8301
p.P898S	MFE-319	endometrium	COSMIC	APTATVRPM	DEG_SIAH_1	904:912	Mutation rewiring degron network	0.1667
p.D604N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	LDETPPQS	DEG_SCF_FBW7_1	600:607	Mutation altering degron motif	0.6932
p.A634T	KATOIII	stomach	COSMIC	PPAY	ITCH	632:635	Mutation altering degron motif	0.6028
p.A634T	PC-14	lung	COSMIC	PPAY	ITCH	632:635	Mutation altering degron motif	0.6028
p.D627G	TK10	kidney	COSMIC	PPAY	ITCH	632:635	Mutation rewiring degron network	0.1944

Kaplan plot for TNK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNK2

UniProt ID: Q07912

Entrez ID: 10188

Protein name: Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNK2 in