DegronMD

Uniprot ID: Q07912

Source protein: Activated CDC42 kinase 1

Source gene: TNK2

Class: DEG_SCF_FBW7_1

Location: 600:607

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 91.7875

COIL: 0.9194

CONS_SCORE: 0.4158

DSS_SCORE: 0.5498

HELIX: 0.0666

FCONS_SCORE: 1.0013

RIG_SCORE: 0.6572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R610Q	DO223732	CESC	ICGC	LDETPPQS	DEG_SCF_FBW7_1	0.25
p.D601N	DO52443	COCA	ICGC	LDETPPQS	DEG_SCF_FBW7_1	0.5821
p.Q606E	DO14566	HNSC	ICGC	LDETPPQS	DEG_SCF_FBW7_1	0.5633
p.Q592K	DO229015	LICA	ICGC	LDETPPQS	DEG_SCF_FBW7_1	0.1111
p.L600M	DO23210	LINC	ICGC	LDETPPQS	DEG_SCF_FBW7_1	0.5999
p.P615L	DO50299	SKCM	ICGC	LDETPPQS	DEG_SCF_FBW7_1	0.1111
p.A596T	DO47773	STAD	ICGC	LDETPPQS	DEG_SCF_FBW7_1	0.2222
p.S600I	SIDM00511	Small Cell Lung Carcinoma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	0.7341
p.S600I	SIDM00887	Other Solid Cancers	GDSC	LDETPPQS	DEG_SCF_FBW7_1	0.7341
p.R616W	SIDM00379	Glioma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	0.0833
p.R616W	SIDM01001	Breast Carcinoma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	0.0833
p.D604V	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LDETPPQS	DEG_SCF_FBW7_1	0.7785
p.P605L	SIDM01318	Hepatocellular Carcinoma	GDSC	LDETPPQS	DEG_SCF_FBW7_1	0.6471
p.E602K	ACH-000293	Endometrial/Uterine Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	0.591
p.M594V	ACH-000323	Brain Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	0.1667
p.A590V	ACH-000972	Endometrial/Uterine Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	0.0556
p.A590V	ACH-000989	Colon/Colorectal Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	0.0556
p.D595G	ACH-001208	Kidney Cancer	CCLE	LDETPPQS	DEG_SCF_FBW7_1	0.1944
p.D595G	TK10	kidney	COSMIC	LDETPPQS	DEG_SCF_FBW7_1	0.1944
p.D604N	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LDETPPQS	DEG_SCF_FBW7_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07912	Activated CDC42 kinase 1	DEG_SCF_FBW7_1	600:607	LDETPPQS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons