DegronMD

Uniprot ID: Q07912

Source protein: Activated CDC42 kinase 1

Source gene: TNK2

Class: ITCH

Location: 632:635

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9991

ASA_SCORE: 78.875

COIL: 0.89

CONS_SCORE: 0.4988

DSS_SCORE: 0.6884

HELIX: 0.068

FCONS_SCORE: 1.2776

RIG_SCORE: 0.6823

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R632W	SIDM00596	Endometrial Carcinoma	GDSC	PPAY	ITCH	0.8634
p.Y635C	ACH-000820	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	0.8198
p.Y635C	SW403	large_intestine	COSMIC	PPAY	ITCH	0.8198
p.P634L	TCGA-75-6214	LUAD	TCGA	PPAY	ITCH	0.7582
p.P632L	DO48547	STAD	ICGC	PPAY	ITCH	0.7582
p.T635N	DO50387	ESAD	ICGC	PPAY	ITCH	0.7055
p.P634S	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	0.6752
p.A634S	DO50898	LICA	ICGC	PPAY	ITCH	0.6477
p.A634T	KATOIII	stomach	COSMIC	PPAY	ITCH	0.6028
p.A634T	PC-14	lung	COSMIC	PPAY	ITCH	0.6028
p.P631A	DO15366	HNSC	ICGC	PPAY	ITCH	0.3056
p.D636E	DO229015	LICA	ICGC	PPAY	ITCH	0.3056
p.R627C	DO233833	GACA	ICGC	PPAY	ITCH	0.1944
p.R627H	DO42673	UCEC	ICGC	PPAY	ITCH	0.1944
p.D627G	TK10	kidney	COSMIC	PPAY	ITCH	0.1944
p.R642L	DO494	BLCA	ICGC	PPAY	ITCH	0.1389
p.G643R	SIDM01316	Ewing's Sarcoma	GDSC	PPAY	ITCH	0.1111
p.D644N	DO51894	BLCA	ICGC	PPAY	ITCH	0.0833
p.A644P	SIDM00849	Kidney Carcinoma	GDSC	PPAY	ITCH	0.0833
p.R622Q	SIDM00276	Biliary Tract Carcinoma	GDSC	PPAY	ITCH	0.0556
p.R622Q	SIDM01434	Hepatocellular Carcinoma	GDSC	PPAY	ITCH	0.0556
p.R622Q	ETK-1	biliary_tract	COSMIC	PPAY	ITCH	0.0556

Showing 1 to 22 of 22 entries

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Drug responses associated with TNK2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PPAY

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07912	Activated CDC42 kinase 1	ITCH	632:635	PPAY	ITCH,NEDD4	0.9991	More...
P37088	Amiloride-sensitive sodium channel subunit alpha	ITCH	641:644	PPAY	ITCH,NEDD4	0.9695	More...
O14497	AT-rich interactive domain-containing protein 1A	ITCH	145:148	PPAY	ITCH,NEDD4	0.9015	More...
Q8NFD5	AT-rich interactive domain-containing protein 1B	ITCH	843:846	PPAY	ITCH,NEDD4	0.9548	More...
Q99700	Ataxin-2	ITCH	1031:1034	PPAY	ITCH,NEDD4	0.991	More...
O95415	Brain protein I3	ITCH	11:14	PPAY	ITCH,NEDD4	0.9941	More...
O75952	Calcium-binding tyrosine phosphorylation-regulated protein	ITCH	270:273	PPAY	ITCH,NEDD4	0.9464	More...
Q8NFW1	Collagen alpha-1	ITCH	1488:1491	PPAY	ITCH,NEDD4	0.9918	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	133:136	PPAY	ITCH,NEDD4	0.993	More...
Q8IV13	Cyclin-J-like protein	ITCH	330:333	PPAY	ITCH,NEDD4	0.9938	More...
O75909	Cyclin-K	ITCH	462:465	PPAY	ITCH,NEDD4	0.5914	More...
Q15038	DAZ-associated protein 2	ITCH	39:42	PPAY	ITCH,NEDD4	0.9779	More...
Q96EP0	E3 ubiquitin-protein ligase RNF31	ITCH	1046:1049	PPAY	ITCH,NEDD4	0.6799	More...
P18146	Early growth response protein 1	ITCH	237:240	PPAY	ITCH,NEDD4	0.9972	More...
A6NMB9	Fidgetin-like protein 2	ITCH	415:418	PPAY	ITCH,NEDD4	0.9107	More...
Q8N144	Gap junction delta-3 protein	ITCH	262:265	PPAY	ITCH,NEDD4	0.9919	More...
Q9BUJ2	Heterogeneous nuclear ribonucleoprotein U-like protein 1	ITCH	781:784	PPAY	ITCH,NEDD4	0.9594	More...
A6NMT0	Homeobox protein DBX1	ITCH	50:53	PPAY	ITCH,NEDD4	0.9932	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	ITCH	156:159	PPAY	ITCH,NEDD4	0.9989	More...
Q96JM7	Lethal	ITCH	84:87	PPAY	ITCH,NEDD4	0.8976	More...
O43561	Linker for activation of T-cells family member 1	ITCH	61:64	PPAY	ITCH,NEDD4	0.9978	More...
Q16655	Melanoma antigen recognized by T-cells 1	ITCH	101:104	PPAY	ITCH,NEDD4	0.9993	More...
O75121	Microfibrillar-associated protein 3-like	ITCH	384:387	PPAY	ITCH,NEDD4	0.9598	More...
Q15797	Mothers against decapentaplegic homolog 1	ITCH	224:227	PPAY	ITCH,NEDD4	0.9965	More...
Q99717	Mothers against decapentaplegic homolog 5	ITCH	223:226	PPAY	ITCH,NEDD4	0.9821	More...

Showing 1 to 25 of 64 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPAY

Degron related mutations and impact score

Drug responses associated with TNK2 mutations

All proteins holding degron of PPAY