DegronMD - Q5ST30(VARS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R393Q	TCGA-AJ-A3EL	UCEC	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7329
p.Q394H	TCGA-AX-A2HD	UCEC	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7582
p.P108S	TCGA-B5-A3FA	UCEC	TCGA	PPAY	ITCH	101:104	Mutation rewiring degron network	0.2222
p.G392R	TCGA-HJ-7597	STAD	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7568
p.D384N	TCGA-VQ-A8PJ	STAD	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.1389
p.R396H	TCGA-XK-AAIW	PRAD	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.8244
p.A111S	DO51927	BLCA	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.1389
p.P101S	DO234320	ESAD	ICGC	PPAY	ITCH	101:104	Mutation altering degron motif	0.6752
p.E403K	DO21085	LAML	ICGC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.1944
p.G91S	DO229192	THCA	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.0556
p.S398N	DO42280	UCEC	ICGC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7069
p.R407Q	DO43154	UCEC	ICGC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.0833
p.R107Q	DO41572	UCEC	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.25
p.S105N	DO41331	UCEC	ICGC	PPAY	ITCH	101:104	Mutation rewiring degron network	0.3056
p.K93N	DO41379	UCEC	ICGC	PPAY	ITCH	101:104	Mutation substituting flanking lysine	0.2222
p.P405L	SIDM00396	Acute Myeloid Leukemia	GDSC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.1389
p.L390V	SIDM00767	Small Cell Lung Carcinoma	GDSC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.3056
p.L390V	NCI-H187	lung	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.3056
p.T388M	ACH-000967	Colon/Colorectal Cancer	CCLE	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.25
p.T388M	ACH-001199	Colon/Colorectal Cancer	CCLE	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.25
p.T388M	SNU-C2B	large intestine	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.25
p.Q392R	A549	lung	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7329
p.W388R	SNU-1040	large intestine	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.25

Kaplan plot for VARS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VARS2

UniProt ID: Q5ST30

Entrez ID: 57176

Protein name: Valine--tRNA ligase, mitochondrial (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) (Valyl-tRNA synthetase-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VARS2 in