DegronMD

Uniprot ID: Q5ST30

Source protein: Valine--tRNA ligase, mitochondrial

Source gene: VARS2

Class: DEG_SCF_FBW7_1

Location: 391:398

E3 ligase: FBXW7

DEGRON score: 0.7105

ASA_SCORE: 19.775

COIL: 0.6716

CONS_SCORE: 0.8808

DSS_SCORE: 0.5287

HELIX: 0.016

FCONS_SCORE: 1.3405

RIG_SCORE: 0.7085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R393Q	TCGA-AJ-A3EL	UCEC	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	0.7329
p.Q394H	TCGA-AX-A2HD	UCEC	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	0.7582
p.G392R	TCGA-HJ-7597	STAD	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	0.7568
p.D384N	TCGA-VQ-A8PJ	STAD	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	0.1389
p.R396H	TCGA-XK-AAIW	PRAD	TCGA	VKVTPAHS	DEG_SCF_FBW7_1	0.8244
p.E403K	DO21085	LAML	ICGC	VKVTPAHS	DEG_SCF_FBW7_1	0.1944
p.S398N	DO42280	UCEC	ICGC	VKVTPAHS	DEG_SCF_FBW7_1	0.7069
p.R407Q	DO43154	UCEC	ICGC	VKVTPAHS	DEG_SCF_FBW7_1	0.0833
p.P405L	SIDM00396	Acute Myeloid Leukemia	GDSC	VKVTPAHS	DEG_SCF_FBW7_1	0.1389
p.L390V	SIDM00767	Small Cell Lung Carcinoma	GDSC	VKVTPAHS	DEG_SCF_FBW7_1	0.3056
p.L390V	NCI-H187	lung	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	0.3056
p.T388M	ACH-000967	Colon/Colorectal Cancer	CCLE	VKVTPAHS	DEG_SCF_FBW7_1	0.25
p.T388M	ACH-001199	Colon/Colorectal Cancer	CCLE	VKVTPAHS	DEG_SCF_FBW7_1	0.25
p.T388M	SNU-C2B	large_intestine	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	0.25
p.Q392R	A549	lung	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	0.7329
p.W388R	SNU-1040	large_intestine	COSMIC	VKVTPAHS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5ST30	Valine--tRNA ligase, mitochondrial	DEG_SCF_FBW7_1	391:398	VKVTPAHS	FBXW7	0.7105	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons