DegronMD - P78314(SH3BP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A212T	TCGA-06-5416	GBM	TCGA	PPAY	ITCH	201:204	Mutation rewiring degron network	0.1111
p.D310G	TCGA-63-A5MM	LUSC	TCGA	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.D310G	DO219153	LUSC	ICGC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.C324Y	TCGA-A6-6653	COAD	TCGA	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.C324Y	DO10373	COAD	ICGC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.R320W	TCGA-AX-A06F	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320W	TCGA-CM-4752	COAD	TCGA	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320W	DO9322	COAD	ICGC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320W	DO233646	GACA	ICGC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320W	DO41752	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320W	SIDM01210	Glioblastoma	GDSC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320W	KNS-81-FD	central nervous system	COSMIC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.S208I	TCGA-AX-A1CE	UCEC	TCGA	PPAY	ITCH	201:204	Mutation rewiring degron network	0.2222
p.S208I	DO42280	UCEC	ICGC	PPAY	ITCH	201:204	Mutation rewiring degron network	0.2222
p.E191K	TCGA-EO-A22R	UCEC	TCGA	PPAY	ITCH	201:204	Mutation rewiring degron network	0.0556
p.E309K	TCGA-QK-A6VC	HNSC	TCGA	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.E309K	DO219056	HNSC	ICGC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.D205N	DO220879	MELA	ICGC	PPAY	ITCH	201:204	Mutation rewiring degron network	0.3056
p.S328Y	DO42472	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.P318R	SIDM00309	Mesothelioma	GDSC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7512
p.P318R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7512
p.P318L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7582
p.P318L	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7582
p.R213K	ACH-000965	Endometrial/Uterine Cancer	CCLE	PPAY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.R213K	RL95-2	endometrium	COSMIC	PPAY	ITCH	201:204	Mutation rewiring degron network	0.0833
p.M199I	ACH-000981	Leukemia	CCLE	PPAY	ITCH	201:204	Mutation rewiring degron network	0.2778
p.M199I	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	201:204	Mutation rewiring degron network	0.2778
p.P310L	ACH-000987	Skin Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.P310L	Mewo	skin	COSMIC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.A324T	ACH-000991	Colon/Colorectal Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.A324T	SNU-81	large intestine	COSMIC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.P206S	ACH-001624	Brain Cancer	CCLE	PPAY	ITCH	201:204	Mutation rewiring degron network	0.2778
p.P207S	ACH-002165	Skin Cancer	CCLE	PPAY	ITCH	201:204	Mutation rewiring degron network	0.25
p.P207S	MZ2-MEL	skin	COSMIC	PPAY	ITCH	201:204	Mutation rewiring degron network	0.25
p.M305I	JSC-1	haematopoietic and lymphoid tissue	COSMIC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0833
p.P210S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	201:204	Mutation rewiring degron network	0.1667
p.R320Q	HT-1080	soft tissue	COSMIC	ACSTS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SH3BP2

UniProt ID: P78314

Entrez ID: 6452

Protein name: SH3 domain-binding protein 2 (3BP-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SH3BP2 in