DegronMD

Uniprot ID: P78314

Source protein: SH3 domain-binding protein 2

Source gene: SH3BP2

Class: DEG_SPOP_SBC_1

Location: 314:318

E3 ligase: SPOP

DEGRON score: 0.7557

ASA_SCORE: 66.32

COIL: 0.8002

CONS_SCORE: 0.2718

DSS_SCORE: 0.4722

HELIX: 0.1434

FCONS_SCORE: 0.7946

RIG_SCORE: 0.6725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D310G	TCGA-63-A5MM	LUSC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.2222
p.D310G	DO219153	LUSC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.2222
p.C324Y	TCGA-A6-6653	COAD	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1667
p.C324Y	DO10373	COAD	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.R320W	TCGA-AX-A06F	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.2778
p.R320W	TCGA-CM-4752	COAD	TCGA	ACSTS	DEG_SPOP_SBC_1	0.2778
p.R320W	DO9322	COAD	ICGC	ACSTS	DEG_SPOP_SBC_1	0.2778
p.R320W	DO233646	GACA	ICGC	ACSTS	DEG_SPOP_SBC_1	0.2778
p.R320W	DO41752	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.2778
p.R320W	SIDM01210	Glioblastoma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.2778
p.R320W	KNS-81-FD	central_nervous_system	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.2778
p.E309K	TCGA-QK-A6VC	HNSC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1944
p.E309K	DO219056	HNSC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1944
p.S328Y	DO42472	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.0556
p.P318R	SIDM00309	Mesothelioma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.7512
p.P318R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.7512
p.P318L	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ACSTS	DEG_SPOP_SBC_1	0.7582
p.P318L	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.7582
p.P310L	ACH-000987	Skin Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	0.2222
p.P310L	Mewo	skin	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.2222
p.A324T	ACH-000991	Colon/Colorectal Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	0.1667
p.A324T	SNU-81	large_intestine	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.M305I	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.0833
p.R320Q	HT-1080	soft_tissue	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78314	SH3 domain-binding protein 2	DEG_SPOP_SBC_1	314:318	ACSTS	SPOP	0.7557	More...
Q13003	Glutamate receptor ionotropic, kainate 3	DEG_SPOP_SBC_1	909:913	ACSTS	SPOP	0.9784	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	850:854	ACSTS	SPOP	0.9719	More...
Q9UL49	Transcription factor-like 5 protein	DEG_SPOP_SBC_1	264:268	ACSTS	SPOP	0.8508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons