DegronMD - Q13003(GRIK3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R900H	TCGA-2H-A9GL	ESCA	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0833
p.P903A	TCGA-85-7844	LUSC	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P903A	DO27136	LUSC	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P919H	TCGA-A5-A0GP	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P919H	TCGA-DA-A1I1	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P919H	DO37966	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P919H	DO41109	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.R901W	TCGA-AA-3852	COAD	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1111
p.R901W	DO8471	COAD	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1111
p.P916T	TCGA-AJ-A2QM	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.25
p.P916T	DO43690	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.25
p.P919S	TCGA-D3-A8GC	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P919S	DO50281	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.R900C	TCGA-D3-A8GI	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0833
p.R900C	DO50284	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0833
p.S911R	TCGA-DX-A7EL	SARC	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation altering degron motif	0.7427
p.S911R	DO220024	SARC	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation altering degron motif	0.7427
p.P903T	TCGA-FI-A2D6	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P903T	DO43867	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.M908I	TCGA-FR-A726	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.3056
p.M908I	DO48665	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.3056
p.P903S	TCGA-Z2-AA3V	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.P903S	DO51303	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.R901Q	DO52760	CMDI	ICGC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1111
p.R901Q	SIDM01292	Esophageal Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1111
p.D899E	SIDM02075	Colorectal Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0556
p.G904S	SIDM00216	Colorectal Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1944
p.G904S	ACH-000989	Colon/Colorectal Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1944
p.G904S	SNU-175	large intestine	COSMIC	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1944
p.T912A	ACH-001061	Colon/Colorectal Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	909:913	Mutation altering degron motif	0.7139

Kaplan plot for GRIK3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GRIK3

UniProt ID: Q13003

Entrez ID: 2899

Protein name: Glutamate receptor ionotropic, kainate 3 (GluK3) (Excitatory amino acid receptor 5) (EAA5) (Glutamate receptor 7) (GluR-7) (GluR7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GRIK3 in