DegronMD

Uniprot ID: Q13003

Source protein: Glutamate receptor ionotropic, kainate 3

Source gene: GRIK3

Class: DEG_SPOP_SBC_1

Location: 909:913

E3 ligase: SPOP

DEGRON score: 0.9784

ASA_SCORE: 72.84

COIL: 0.7594

CONS_SCORE: 0.2791

DSS_SCORE: 0.5071

HELIX: 0.1672

FCONS_SCORE: 1.0049

RIG_SCORE: 0.7331

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R900H	TCGA-2H-A9GL	ESCA	TCGA	ACSTS	DEG_SPOP_SBC_1	0.0833
p.P903A	TCGA-85-7844	LUSC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P903A	DO27136	LUSC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P919H	TCGA-A5-A0GP	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P919H	TCGA-DA-A1I1	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P919H	DO37966	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P919H	DO41109	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.R901W	TCGA-AA-3852	COAD	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1111
p.R901W	DO8471	COAD	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1111
p.P916T	TCGA-AJ-A2QM	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.25
p.P916T	DO43690	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.25
p.P919S	TCGA-D3-A8GC	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P919S	DO50281	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.R900C	TCGA-D3-A8GI	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	0.0833
p.R900C	DO50284	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	0.0833
p.S911R	TCGA-DX-A7EL	SARC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.7427
p.S911R	DO220024	SARC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.7427
p.P903T	TCGA-FI-A2D6	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P903T	DO43867	UCEC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.M908I	TCGA-FR-A726	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	0.3056
p.M908I	DO48665	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	0.3056
p.P903S	TCGA-Z2-AA3V	SKCM	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1667
p.P903S	DO51303	SKCM	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1667
p.R901Q	DO52760	CMDI	ICGC	ACSTS	DEG_SPOP_SBC_1	0.1111
p.R901Q	SIDM01292	Esophageal Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.1111
p.D899E	SIDM02075	Colorectal Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.0556
p.G904S	SIDM00216	Colorectal Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.1944
p.G904S	ACH-000989	Colon/Colorectal Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	0.1944
p.G904S	SNU-175	large_intestine	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.1944
p.T912A	ACH-001061	Colon/Colorectal Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78314	SH3 domain-binding protein 2	DEG_SPOP_SBC_1	314:318	ACSTS	SPOP	0.7557	More...
Q13003	Glutamate receptor ionotropic, kainate 3	DEG_SPOP_SBC_1	909:913	ACSTS	SPOP	0.9784	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	850:854	ACSTS	SPOP	0.9719	More...
Q9UL49	Transcription factor-like 5 protein	DEG_SPOP_SBC_1	264:268	ACSTS	SPOP	0.8508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ACSTS

Degron related mutations and impact score

Drug responses associated with GRIK3 mutations

All proteins holding degron of ACSTS