DegronMD

Uniprot ID: Q9UL49

Source protein: Transcription factor-like 5 protein

Source gene: TCFL5

Class: DEG_SPOP_SBC_1

Location: 264:268

E3 ligase: SPOP

DEGRON score: 0.8508

ASA_SCORE: 56.68

COIL: 0.8378

CONS_SCORE: 0.7586

DSS_SCORE: 0.2977

HELIX: 0.0846

FCONS_SCORE: 0.9386

RIG_SCORE: 0.7455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L273I	TCGA-AP-A056	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.1944
p.A264T	TCGA-AP-A0LM	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	0.7139
p.R270T	DO15959	HNSC	ICGC	ACSTS	DEG_SPOP_SBC_1	0.2778
p.T256I	SIDM00272	Breast Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.1111
p.T256I	ACH-000910	Breast Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	0.1111
p.T256I	MDA-MB-453	breast	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.1111
p.Y257C	SIDM01608	Endometrial Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	0.1389
p.Y257C	ACH-000990	Endometrial/Uterine Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	0.1389
p.T266M	HCC1569	breast	COSMIC	ACSTS	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P78314	SH3 domain-binding protein 2	DEG_SPOP_SBC_1	314:318	ACSTS	SPOP	0.7557	More...
Q13003	Glutamate receptor ionotropic, kainate 3	DEG_SPOP_SBC_1	909:913	ACSTS	SPOP	0.9784	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	850:854	ACSTS	SPOP	0.9719	More...
Q9UL49	Transcription factor-like 5 protein	DEG_SPOP_SBC_1	264:268	ACSTS	SPOP	0.8508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons