DegronMD - Q9UL49(TCFL5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R348C	TCGA-78-7537	LUAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.R348C	TCGA-AD-5900	COAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.R348C	TCGA-AX-A06F	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.R348C	TCGA-E1-5311	LGG	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.R348C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.R348C	ACH-001127	Leukemia	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.R348C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.D351G	TCGA-A5-A1OF	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.2222
p.A371T	TCGA-A6-6648	COAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.G366S	TCGA-AN-A0AK	BRCA	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.L273I	TCGA-AP-A056	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1944
p.A264T	TCGA-AP-A0LM	UCEC	TCGA	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7139
p.R348H	TCGA-AX-A1CE	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.R348H	TCGA-BR-8361	STAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.E361K	TCGA-CR-7388	HNSC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.591
p.G368R	TCGA-D7-A6EZ	STAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1944
p.R356Q	TCGA-EO-A22X	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.7329
p.E355D	DO219049	BLCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5647
p.E355D	DO50727	ORCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5647
p.Q352E	DO474	BLCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25
p.G345W	DO225215	BRCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0556
p.G345W	DO227836	BRCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.0556
p.R369H	DO234389	ESAD	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.R270T	DO15959	HNSC	ICGC	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.2778
p.R369L	DO25189	LUAD	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1667
p.A371V	SIDM00933	Breast Carcinoma	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.A371V	ACH-000856	Breast Cancer	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.A371V	CAL-51	breast	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1111
p.T256I	SIDM00272	Breast Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1111
p.T256I	ACH-000910	Breast Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1111
p.T256I	MDA-MB-453	breast	COSMIC	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1111
p.E355K	SIDM00146	Breast Carcinoma	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.591
p.E355K	ACH-000768	Breast Cancer	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.591
p.E355K	MDA-MB-231	breast	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.591
p.Y257C	SIDM01608	Endometrial Carcinoma	GDSC	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1389
p.Y257C	ACH-000990	Endometrial/Uterine Cancer	CCLE	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation rewiring degron network	0.1389
p.I362V	SIDM01612	Endometrial Carcinoma	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5965
p.I362V	ACH-000946	Endometrial/Uterine Cancer	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation altering degron motif	0.5965
p.G348R	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.1389
p.T266M	HCC1569	breast	COSMIC	ACSTS	DEG_SPOP_SBC_1	264:268	Mutation altering degron motif	0.7423
p.R366C	SNU-1040	large intestine	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	355:363	Mutation rewiring degron network	0.25

Kaplan plot for TCFL5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCFL5

UniProt ID: Q9UL49

Entrez ID: 10732

Protein name: Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TCFL5 in