DegronMD

Uniprot ID: Q9UL49

Source protein: Transcription factor-like 5 protein

Source gene: TCFL5

Class: DEG_APCC_DBOX_1

Location: 355:363

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9946

ASA_SCORE: 105.7111

COIL: 0.4947

CONS_SCORE: 0.8491

DSS_SCORE: 0.4551

HELIX: 0.4792

FCONS_SCORE: 1.2549

RIG_SCORE: 0.7645

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R348C	TCGA-78-7537	LUAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R348C	TCGA-AD-5900	COAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R348C	TCGA-AX-A06F	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R348C	TCGA-E1-5311	LGG	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R348C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R348C	ACH-001127	Leukemia	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R348C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.D351G	TCGA-A5-A1OF	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.2222
p.A371T	TCGA-A6-6648	COAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1111
p.G366S	TCGA-AN-A0AK	BRCA	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.25
p.R348H	TCGA-AX-A1CE	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R348H	TCGA-BR-8361	STAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.E361K	TCGA-CR-7388	HNSC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.591
p.G368R	TCGA-D7-A6EZ	STAD	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.1944
p.R356Q	TCGA-EO-A22X	UCEC	TCGA	ERRALGEIQ	DEG_APCC_DBOX_1	0.7329
p.E355D	DO219049	BLCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	0.5647
p.E355D	DO50727	ORCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	0.5647
p.Q352E	DO474	BLCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	0.25
p.G345W	DO225215	BRCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	0.0556
p.G345W	DO227836	BRCA	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	0.0556
p.R369H	DO234389	ESAD	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	0.1667
p.R369L	DO25189	LUAD	ICGC	ERRALGEIQ	DEG_APCC_DBOX_1	0.1667
p.A371V	SIDM00933	Breast Carcinoma	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	0.1111
p.A371V	ACH-000856	Breast Cancer	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	0.1111
p.A371V	CAL-51	breast	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	0.1111
p.E355K	SIDM00146	Breast Carcinoma	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	0.591
p.E355K	ACH-000768	Breast Cancer	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	0.591
p.E355K	MDA-MB-231	breast	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	0.591
p.I362V	SIDM01612	Endometrial Carcinoma	GDSC	ERRALGEIQ	DEG_APCC_DBOX_1	0.5965
p.I362V	ACH-000946	Endometrial/Uterine Cancer	CCLE	ERRALGEIQ	DEG_APCC_DBOX_1	0.5965
p.G348R	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	0.1389
p.R366C	SNU-1040	large_intestine	COSMIC	ERRALGEIQ	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERRALGEIQ

Degron related mutations and impact score

Drug responses associated with TCFL5 mutations

All proteins holding degron of ERRALGEIQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL49	Transcription factor-like 5 protein	DEG_APCC_DBOX_1	355:363	ERRALGEIQ	APC,CDC20,FZR1	0.9946	More...