DegronMD - Q5T5C0(STXBP5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1046E	TCGA-21-1083	LUSC	TCGA	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.1389
p.Q580L	TCGA-33-4582	LUSC	TCGA	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.25
p.Q580L	DO26698	LUSC	ICGC	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.25
p.R594C	TCGA-BS-A0UV	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1389
p.R594C	DO42793	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1389
p.G1031S	TCGA-DD-AACV	LIHC	TCGA	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.2778
p.S1068L	TCGA-EE-A29D	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.3056
p.F1034L	TCGA-EE-A2GC	SKCM	TCGA	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.587
p.G592V	TCGA-EE-A2GH	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1944
p.G592V	DO37643	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.1944
p.P1036H	TCGA-EE-A2MM	SKCM	TCGA	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.7694
p.S19L	TCGA-EE-A2MR	SKCM	TCGA	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1944
p.S19L	DO37819	SKCM	ICGC	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1944
p.F1047L	TCGA-EO-A3AV	UCEC	TCGA	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.1111
p.G868C	TCGA-F1-6874	STAD	TCGA	PPAY	ITCH	872:875	Mutation rewiring degron network	0.2222
p.G16S	TCGA-FS-A1ZC	SKCM	TCGA	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2778
p.G16S	DO37487	SKCM	ICGC	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2778
p.P1036L	TCGA-IB-7651	PAAD	TCGA	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.7582
p.Q22L	TCGA-OR-A5JZ	ACC	TCGA	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1111
p.S589L	TCGA-XF-A9T0	BLCA	TCGA	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.2778
p.S589L	DO51920	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	583:587	Mutation rewiring degron network	0.2778
p.I881V	DO51631	CESC	ICGC	PPAY	ITCH	872:875	Mutation rewiring degron network	0.1667
p.G1049C	DO230335	COCA	ICGC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation substituting flanking lysine	0.1667
p.G1030R	DO233625	GACA	ICGC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.25
p.S866F	DO233749	GACA	ICGC	PPAY	ITCH	872:875	Mutation rewiring degron network	0.1667
p.G1076R	DO12124	GBM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation blocking phosphorylation signal	0.5278
p.G1076V	DO229034	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation blocking phosphorylation signal	0.5278
p.V1062G	DO228901	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.7532
p.G1053S	DO50970	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.1111
p.A1071S	DO25416	LUAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.2222
p.E1052K	DO23862	LUAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.0833
p.R1067Q	DO222595	MELA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.7329
p.G16D	DO229490	PRAD	ICGC	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2778
p.P867L	DO47401	SKCM	ICGC	PPAY	ITCH	872:875	Mutation rewiring degron network	0.1944
p.S1032L	DO38123	SKCM	ICGC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.3056
p.A1066V	DO229232	THCA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.6936
p.Q1043R	DO219774	UCEC	ICGC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.2222
p.R1075I	DO41572	UCEC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.1111
p.A879T	DO42568	UCEC	ICGC	PPAY	ITCH	872:875	Mutation rewiring degron network	0.2222
p.N876D	DO43755	UCEC	ICGC	PPAY	ITCH	872:875	Mutation rewiring degron network	0.3056
p.K8R	SIDM00545	Melanoma	GDSC	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.6126
p.K8R	Mewo	skin	COSMIC	IRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.6126
p.G1031C	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.2778
p.G1031C	ACH-000706	Lung Cancer	CCLE	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.2778
p.G1031C	EKVX	lung	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.2778
p.E1063Q	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.5633
p.E1063Q	ACH-001680	Lymphoma	CCLE	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.5633
p.E1063Q	U-698-M	haematopoietic and lymphoid tissue	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.5633
p.S1070P	SIDM01045	Endometrial Carcinoma	GDSC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.25
p.S1070P	ACH-000978	Endometrial/Uterine Cancer	CCLE	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.25
p.S1070P	EN	endometrium	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation rewiring degron network	0.25
p.V1037L	SIDM00254	Neuroblastoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.5654
p.V1037L	ACH-002283	Neuroblastoma	CCLE	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.5654
p.V1037L	NB5	autonomic ganglia	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.5654
p.V1037G	SIDM00679	Cervical Carcinoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.6421
p.V1037G	ACH-001525	Cervical Cancer	CCLE	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.6421
p.V1037G	HT-3	cervix	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.6421
p.F1034V	SIDM01450	Gastric Carcinoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.5957
p.F1034V	ACH-000898	Gastric Cancer	CCLE	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.5957
p.L1048I	NCI-H187	lung	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.0833
p.L1048F	SR	haematopoietic and lymphoid tissue	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.0833
p.L1065F	SR	haematopoietic and lymphoid tissue	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.6981
p.S1034P	EN	endometrium	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation altering degron motif	0.6752
p.P1029S	KYSE-140	oesophagus	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.2222
p.P1046S	KYSE-140	oesophagus	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.1389
p.L1065I	NCI-H187	lung	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	1061:1067	Mutation altering degron motif	0.7174
p.P876S	SNU-C5	large intestine	COSMIC	PPAY	ITCH	872:875	Mutation rewiring degron network	0.3056
p.Q877K	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	872:875	Mutation rewiring degron network	0.2778
p.E1027Q	U-698-M	haematopoietic and lymphoid tissue	COSMIC	LFTPVET	DEG_SCF_FBW7_1	1033:1039	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STXBP5

UniProt ID: Q5T5C0

Entrez ID: 134957

Protein name: Syntaxin-binding protein 5 (Lethal(2) giant larvae protein homolog 3) (Tomosyn-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STXBP5 in