DegronMD

Uniprot ID: Q5T5C0

Source protein: Syntaxin-binding protein 5

Source gene: STXBP5

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9442

ASA_SCORE: 67.2556

COIL: 0.498

CONS_SCORE: 0.3432

DSS_SCORE: 0.6491

HELIX: 0.3798

FCONS_SCORE: 1.1604

RIG_SCORE: 0.7506

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S19L	TCGA-EE-A2MR	SKCM	TCGA	IRKVLDGLT	DEG_APCC_DBOX_1	0.1944
p.S19L	DO37819	SKCM	ICGC	IRKVLDGLT	DEG_APCC_DBOX_1	0.1944
p.G16S	TCGA-FS-A1ZC	SKCM	TCGA	IRKVLDGLT	DEG_APCC_DBOX_1	0.2778
p.G16S	DO37487	SKCM	ICGC	IRKVLDGLT	DEG_APCC_DBOX_1	0.2778
p.Q22L	TCGA-OR-A5JZ	ACC	TCGA	IRKVLDGLT	DEG_APCC_DBOX_1	0.1111
p.G16D	DO229490	PRAD	ICGC	IRKVLDGLT	DEG_APCC_DBOX_1	0.2778
p.K8R	SIDM00545	Melanoma	GDSC	IRKVLDGLT	DEG_APCC_DBOX_1	0.6126
p.K8R	Mewo	skin	COSMIC	IRKVLDGLT	DEG_APCC_DBOX_1	0.6126

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5C0	Syntaxin-binding protein 5	DEG_APCC_DBOX_1	6:14	IRKVLDGLT	APC,CDC20,FZR1	0.9442	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons