DegronMD

Uniprot ID: Q5T5C0

Source protein: Syntaxin-binding protein 5

Source gene: STXBP5

Class: DEG_SCF_FBW7_1

Location: 1033:1039

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 77.8571

COIL: 0.846

CONS_SCORE: 0.3721

DSS_SCORE: 0.4835

HELIX: 0.0287

FCONS_SCORE: 1.0893

RIG_SCORE: 0.7937

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1046E	TCGA-21-1083	LUSC	TCGA	LFTPVET	DEG_SCF_FBW7_1	0.1389
p.G1031S	TCGA-DD-AACV	LIHC	TCGA	LFTPVET	DEG_SCF_FBW7_1	0.2778
p.F1034L	TCGA-EE-A2GC	SKCM	TCGA	LFTPVET	DEG_SCF_FBW7_1	0.587
p.P1036H	TCGA-EE-A2MM	SKCM	TCGA	LFTPVET	DEG_SCF_FBW7_1	0.7694
p.F1047L	TCGA-EO-A3AV	UCEC	TCGA	LFTPVET	DEG_SCF_FBW7_1	0.1111
p.P1036L	TCGA-IB-7651	PAAD	TCGA	LFTPVET	DEG_SCF_FBW7_1	0.7582
p.G1049C	DO230335	COCA	ICGC	LFTPVET	DEG_SCF_FBW7_1	0.1667
p.G1030R	DO233625	GACA	ICGC	LFTPVET	DEG_SCF_FBW7_1	0.25
p.S1032L	DO38123	SKCM	ICGC	LFTPVET	DEG_SCF_FBW7_1	0.3056
p.Q1043R	DO219774	UCEC	ICGC	LFTPVET	DEG_SCF_FBW7_1	0.2222
p.G1031C	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	0.2778
p.G1031C	ACH-000706	Lung Cancer	CCLE	LFTPVET	DEG_SCF_FBW7_1	0.2778
p.G1031C	EKVX	lung	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.2778
p.V1037L	SIDM00254	Neuroblastoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	0.5654
p.V1037L	ACH-002283	Neuroblastoma	CCLE	LFTPVET	DEG_SCF_FBW7_1	0.5654
p.V1037L	NB5	autonomic_ganglia	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.5654
p.V1037G	SIDM00679	Cervical Carcinoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	0.6421
p.V1037G	ACH-001525	Cervical Cancer	CCLE	LFTPVET	DEG_SCF_FBW7_1	0.6421
p.V1037G	HT-3	cervix	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.6421
p.F1034V	SIDM01450	Gastric Carcinoma	GDSC	LFTPVET	DEG_SCF_FBW7_1	0.5957
p.F1034V	ACH-000898	Gastric Cancer	CCLE	LFTPVET	DEG_SCF_FBW7_1	0.5957
p.L1048I	NCI-H187	lung	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.0833
p.L1048F	SR	haematopoietic_and_lymphoid_tissue	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.0833
p.S1034P	EN	endometrium	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.6752
p.P1029S	KYSE-140	oesophagus	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.2222
p.P1046S	KYSE-140	oesophagus	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.1389
p.E1027Q	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LFTPVET	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LFTPVET

Degron related mutations and impact score

Drug responses associated with STXBP5 mutations

All proteins holding degron of LFTPVET

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5C0	Syntaxin-binding protein 5	DEG_SCF_FBW7_1	1033:1039	LFTPVET	FBXW7	0.9983	More...