DegronMD

Uniprot ID: Q5T5C0

Source protein: Syntaxin-binding protein 5

Source gene: STXBP5

Class: LIG_APCC_ABBAyCdc20_2

Location: 1061:1067

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9958

ASA_SCORE: 92.3429

COIL: 0.5079

CONS_SCORE: 0.4696

DSS_SCORE: 0.5721

HELIX: 0.4353

FCONS_SCORE: 1.3656

RIG_SCORE: 0.7381

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1068L	TCGA-EE-A29D	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G1076R	DO12124	GBM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.5278
p.G1076V	DO229034	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.5278
p.V1062G	DO228901	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7532
p.G1053S	DO50970	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A1071S	DO25416	LUAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.E1052K	DO23862	LUAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1067Q	DO222595	MELA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7329
p.A1066V	DO229232	THCA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.6936
p.R1075I	DO41572	UCEC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1063Q	SIDM00424	B-Cell Non-Hodgkin's Lymphoma	GDSC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E1063Q	ACH-001680	Lymphoma	CCLE	REELFGE	LIG_APCC_ABBAyCdc20_2	0.5633
p.E1063Q	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.5633
p.S1070P	SIDM01045	Endometrial Carcinoma	GDSC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.S1070P	ACH-000978	Endometrial/Uterine Cancer	CCLE	REELFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.S1070P	EN	endometrium	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.25
p.L1065F	SR	haematopoietic_and_lymphoid_tissue	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.6981
p.L1065I	NCI-H187	lung	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5C0	Syntaxin-binding protein 5	LIG_APCC_ABBAyCdc20_2	1061:1067	REELFGE	APC,CDC20,FZR1	0.9958	More...
Q9Y2K9	Syntaxin-binding protein 5-like	LIG_APCC_ABBAyCdc20_2	1096:1102	REELFGE	APC,CDC20,FZR1	0.8659	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons