DegronMD

Uniprot ID: Q9Y2K9

Source protein: Syntaxin-binding protein 5-like

Source gene: STXBP5L

Class: LIG_APCC_ABBAyCdc20_2

Location: 1096:1102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8659

ASA_SCORE: 90.2286

COIL: 0.4904

CONS_SCORE: 0.4396

DSS_SCORE: 0.5252

HELIX: 0.4119

FCONS_SCORE: 1.2364

RIG_SCORE: 0.7818

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1091R	TCGA-33-AASI	LUSC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G1091R	TCGA-AA-A02R	COAD	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G1091R	DO219129	LUSC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1944
p.F1094S	TCGA-BS-A0UF	UCEC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.F1094S	DO41488	UCEC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G1106E	TCGA-D3-A2JO	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G1106E	TCGA-GF-A3OT	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G1106E	TCGA-YG-AA3N	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R1110S	TCGA-D3-A3CE	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1110S	DO37405	SKCM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.F1094L	TCGA-DA-A95Z	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G1106R	TCGA-EE-A29H	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L1112I	TCGA-EJ-5511	PRAD	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L1112I	ACH-000977	lymph_node	CCLE	REELFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L1112I	LNCaP-Clone-FGC	prostate	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S1104L	TCGA-EO-A22R	UCEC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1104L	TCGA-RP-A693	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1104L	DO51268	SKCM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1104L	DO42713	UCEC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1095G	TCGA-F5-6814	READ	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D1095G	DO36556	READ	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R1110C	TCGA-FI-A2D0	UCEC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1098D	DO228974	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.5647
p.A1104S	DO229041	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G1096R	DO25528	LUAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7568
p.M1101I	DO26546	LUSC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7618
p.M1101I	DO220851	MELA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7618
p.S1097R	DO28001	OV	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7427
p.L1088I	DO36324	PRAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L1088I	LNCaP-Clone-FGC	prostate	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.1111
p.I1098T	DO37861	SKCM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: REELFGE

Degron related mutations and impact score

Drug responses associated with STXBP5L mutations

All proteins holding degron of REELFGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5C0	Syntaxin-binding protein 5	LIG_APCC_ABBAyCdc20_2	1061:1067	REELFGE	APC,CDC20,FZR1	0.9958	More...
Q9Y2K9	Syntaxin-binding protein 5-like	LIG_APCC_ABBAyCdc20_2	1096:1102	REELFGE	APC,CDC20,FZR1	0.8659	More...