DegronMD - Q9Y2K9(STXBP5L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1081C	TCGA-21-1080	LUSC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.6489
p.G1081C	DO26502	LUSC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.6489
p.G1091R	TCGA-33-AASI	LUSC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.2222
p.G1091R	TCGA-33-AASI	LUSC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1944
p.G1091R	TCGA-AA-A02R	COAD	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.2222
p.G1091R	TCGA-AA-A02R	COAD	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1944
p.G1091R	DO219129	LUSC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.2222
p.G1091R	DO219129	LUSC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1944
p.F1069Y	TCGA-34-2609	LUSC	TCGA	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation altering degron motif	0.6417
p.A252T	TCGA-37-3792	LUSC	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.2778
p.A252T	DO27192	LUSC	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.2778
p.P576L	TCGA-43-5668	LUSC	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.2222
p.P576L	TCGA-D3-A8GC	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.2222
p.P576L	DO26608	LUSC	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.2222
p.P576L	DO50281	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.2222
p.K1084E	TCGA-55-7994	LUAD	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.591
p.T1070A	TCGA-5M-AAT6	COAD	TCGA	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation altering degron motif	0.7139
p.T1070A	DO223703	COAD	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation altering degron motif	0.7139
p.E251D	TCGA-78-7536	LUAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.E251D	DO26414	LUAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.G1066E	TCGA-90-A4EE	LUSC	TCGA	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.2778
p.G1066E	DO45513	LUSC	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.2778
p.L580P	TCGA-91-6836	LUAD	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1111
p.L580P	DO23854	LUAD	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1111
p.E251K	TCGA-95-7039	LUAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.E251K	TCGA-W3-AA1V	SKCM	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.E251K	DO23907	LUAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.E251K	DO51276	SKCM	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.L1083F	TCGA-AA-A00N	COAD	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.6981
p.H260N	TCGA-AA-A010	COAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.H260N	DO233249	GACA	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.T1070I	TCGA-AN-A046	BRCA	TCGA	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation altering degron motif	0.7078
p.I566V	TCGA-AP-A0LM	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation altering degron motif	0.5965
p.I566V	DO43306	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation altering degron motif	0.5965
p.P578T	TCGA-AX-A05Z	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1667
p.P578T	DO40884	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1667
p.G19D	TCGA-AX-A0J0	UCEC	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1944
p.G19D	DO41133	UCEC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1944
p.L1083I	TCGA-AX-A0J0	UCEC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.7174
p.V563A	TCGA-B5-A11E	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.25
p.V563A	TCGA-W3-AA1Q	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.25
p.V563A	DO219487	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.25
p.V563A	DO41644	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.25
p.S255L	TCGA-BF-A1Q0	SKCM	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.S255L	DO47374	SKCM	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.K8N	TCGA-BS-A0UF	UCEC	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.5806
p.K8N	DO41488	UCEC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.5806
p.F1094S	TCGA-BS-A0UF	UCEC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.1389
p.F1094S	TCGA-BS-A0UF	UCEC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.F1094S	DO41488	UCEC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.1389
p.F1094S	DO41488	UCEC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.H260R	TCGA-D1-A2G5	UCEC	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.H260R	DO40918	UCEC	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.G1106E	TCGA-D3-A2JO	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2222
p.G1106E	TCGA-GF-A3OT	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2222
p.G1106E	TCGA-YG-AA3N	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2222
p.S17Y	TCGA-D3-A3CE	SKCM	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.S17Y	DO37405	SKCM	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.R1110S	TCGA-D3-A3CE	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1111
p.R1110S	DO37405	SKCM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1111
p.D1067Y	TCGA-D5-6928	COAD	TCGA	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.3056
p.P576S	TCGA-DA-A3F8	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.2222
p.P576S	DO37418	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.2222
p.F1094L	TCGA-DA-A95Z	SKCM	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.1389
p.F1094L	TCGA-DA-A95Z	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.R246S	TCGA-DK-A6AW	BLCA	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6316
p.R246S	DO48566	BLCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.6316
p.E1076Q	TCGA-DK-A6B2	BLCA	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.25
p.E1076Q	TCGA-DK-A6B2	BLCA	TCGA	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.2778
p.E1076Q	DO48543	BLCA	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.25
p.E1076Q	DO48543	BLCA	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.2778
p.G1106R	TCGA-EE-A29H	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2222
p.P575S	TCGA-EE-A3JD	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.25
p.P575S	DO50299	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.25
p.L1112I	TCGA-EJ-5511	PRAD	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.0556
p.L1112I	ACH-000977	lymph node	CCLE	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.0556
p.L1112I	LNCaP-Clone-FGC	prostate	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.0556
p.S1104L	TCGA-EO-A22R	UCEC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.S1104L	TCGA-RP-A693	SKCM	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.S1104L	DO51268	SKCM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.S1104L	DO42713	UCEC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.L580F	TCGA-ER-A19G	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1111
p.L580F	DO47284	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1111
p.P18T	TCGA-ER-A1A1	SKCM	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2222
p.P18T	DO37413	SKCM	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2222
p.H260Y	TCGA-ER-A42L	SKCM	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.H260Y	DO223910	SKCM	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0556
p.K2N	TCGA-EY-A1GD	UCEC	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation substituting flanking lysine	0.3333
p.K2N	DO42129	UCEC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation substituting flanking lysine	0.3333
p.K2N	SIDM01588	Endometrial Carcinoma	GDSC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation substituting flanking lysine	0.3333
p.K2N	ACH-000993	Endometrial/Uterine Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation substituting flanking lysine	0.3333
p.D1095G	TCGA-F5-6814	READ	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.1111
p.D1095G	TCGA-F5-6814	READ	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.3056
p.D1095G	DO36556	READ	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.1111
p.D1095G	DO36556	READ	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.3056
p.W236C	TCGA-FD-A6TB	BLCA	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.W236C	DO51879	BLCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.0833
p.R558Q	TCGA-FI-A2D0	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1111
p.R558Q	DO43891	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1111
p.R1110C	TCGA-FI-A2D0	UCEC	TCGA	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1111
p.D237G	TCGA-HU-A4H0	STAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.D237G	DO47785	STAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.L238F	TCGA-KQ-A41N	BLCA	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1389
p.L238F	DO223588	BLCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1389
p.E251V	TCGA-L9-A7SV	LUAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.E251V	DO49875	LUAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.3056
p.V247F	TCGA-XK-AAIW	PRAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.7068
p.V247F	DO51407	PRAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.7068
p.L1059F	DO9876	COAD	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.0833
p.E556Q	DO50403	ESAD	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.0556
p.E564G	DO234356	ESAD	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.2778
p.T573R	DO228667	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.3056
p.E1098D	DO228974	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation altering degron motif	0.5647
p.A1077S	DO229029	LICA	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.2778
p.A1077S	DO229029	LICA	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.25
p.Q560H	DO229034	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1667
p.V563F	DO229034	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.25
p.A1104S	DO229041	LICA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.2778
p.V557L	DO229041	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.0833
p.S16T	DO23362	LINC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2778
p.G1096R	DO25528	LUAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation altering degron motif	0.7568
p.K1060E	DO45311	LUAD	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.1111
p.M1101I	DO26546	LUSC	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation altering degron motif	0.7618
p.M1101I	DO220851	MELA	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation altering degron motif	0.7618
p.R1086C	DO222843	MELA	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.8301
p.R1086C	DO43891	UCEC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.8301
p.S1097R	DO28001	OV	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation altering degron motif	0.7427
p.L1088I	DO36324	PRAD	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.3056
p.L1088I	DO36324	PRAD	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1111
p.L1088I	LNCaP-Clone-FGC	prostate	COSMIC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation rewiring degron network	0.3056
p.L1088I	LNCaP-Clone-FGC	prostate	COSMIC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation rewiring degron network	0.1111
p.G1082R	DO37535	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.7568
p.I1098T	DO37861	SKCM	ICGC	REELFGE	LIG_APCC_ABBAyCdc20_2	1096:1102	Mutation altering degron motif	0.7078
p.G1082E	DO47288	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.7199
p.G1082E	DO47619	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.7199
p.G1082E	DO51298	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.7199
p.F1070L	DO219481	SKCM	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation altering degron motif	0.6981
p.S240Y	DO229213	THCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1944
p.L1059I	DO41133	UCEC	ICGC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.0833
p.K8I	SIDM00545	Melanoma	GDSC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.642
p.K8I	ACH-000987	Skin Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.642
p.K8I	Mewo	skin	COSMIC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.642
p.V247I	SIDM00041	Gastric Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.5965
p.V247I	ACH-002306	Gastric Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.5965
p.V247I	STS-0421	soft tissue	COSMIC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation altering degron motif	0.5965
p.S23N	SIDM00660	Colorectal Carcinoma	GDSC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.0833
p.S23N	ACH-000985	Colon/Colorectal Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.0833
p.S23N	LS-411N	large intestine	COSMIC	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.0833
p.F1087I	SIDM00333	Endometrial Carcinoma	GDSC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.6304
p.F1087I	ACH-000988	Endometrial/Uterine Cancer	CCLE	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.6304
p.F1087I	MFE-319	endometrium	COSMIC	NRGFLKGLF	DEG_APCC_DBOX_1	1079:1087	Mutation altering degron motif	0.6304
p.D237E	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.D237E	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.D237E	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.D237E	ACH-000681	Lung Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.D237E	ACH-002337	Lung Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.D237E	A549	lung	COSMIC	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.1111
p.R558P	ACH-001698	Head and Neck Cancer	CCLE	IITPEPE	DEG_SCF_FBW7_2	566:572	Mutation rewiring degron network	0.1111
p.I253V	ACH-002016	Eye Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	245:250	Mutation rewiring degron network	0.25
p.S17F	ACH-002024	Colon/Colorectal Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.F1063I	MFE-319	endometrium	COSMIC	LFTPIET	DEG_SCF_FBW7_1	1068:1074	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STXBP5L

UniProt ID: Q9Y2K9

Entrez ID: 9515

Protein name: Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STXBP5L in