DegronMD

Uniprot ID: Q9Y2K9

Source protein: Syntaxin-binding protein 5-like

Source gene: STXBP5L

Class: LIG_APCC_ABBA_1

Location: 245:250

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5651

ASA_SCORE: 58.1667

COIL: 0.3308

CONS_SCORE: 0.3276

DSS_SCORE: 0.0572

HELIX: 0.0025

FCONS_SCORE: 0.7352

RIG_SCORE: 0.9024

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A252T	TCGA-37-3792	LUSC	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.2778
p.A252T	DO27192	LUSC	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.2778
p.E251D	TCGA-78-7536	LUAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.E251D	DO26414	LUAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.E251K	TCGA-95-7039	LUAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.E251K	TCGA-W3-AA1V	SKCM	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.E251K	DO23907	LUAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.E251K	DO51276	SKCM	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.H260N	TCGA-AA-A010	COAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.0556
p.H260N	DO233249	GACA	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.0556
p.S255L	TCGA-BF-A1Q0	SKCM	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.1944
p.S255L	DO47374	SKCM	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.1944
p.H260R	TCGA-D1-A2G5	UCEC	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.0556
p.H260R	DO40918	UCEC	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.0556
p.R246S	TCGA-DK-A6AW	BLCA	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.6316
p.R246S	DO48566	BLCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.6316
p.H260Y	TCGA-ER-A42L	SKCM	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.0556
p.H260Y	DO223910	SKCM	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.0556
p.W236C	TCGA-FD-A6TB	BLCA	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.0833
p.W236C	DO51879	BLCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.0833
p.D237G	TCGA-HU-A4H0	STAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.D237G	DO47785	STAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.L238F	TCGA-KQ-A41N	BLCA	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.1389
p.L238F	DO223588	BLCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.1389
p.E251V	TCGA-L9-A7SV	LUAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.E251V	DO49875	LUAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.3056
p.V247F	TCGA-XK-AAIW	PRAD	TCGA	LRVYYD	LIG_APCC_ABBA_1	0.7068
p.V247F	DO51407	PRAD	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.7068
p.S240Y	DO229213	THCA	ICGC	LRVYYD	LIG_APCC_ABBA_1	0.1944
p.V247I	SIDM00041	Gastric Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	0.5965
p.V247I	ACH-002306	Gastric Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	0.5965
p.V247I	STS-0421	soft_tissue	COSMIC	LRVYYD	LIG_APCC_ABBA_1	0.5965
p.D237E	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.D237E	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.D237E	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.D237E	ACH-000681	Lung Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.D237E	ACH-002337	Lung Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.D237E	A549	lung	COSMIC	LRVYYD	LIG_APCC_ABBA_1	0.1111
p.I253V	ACH-002016	Eye Cancer	CCLE	LRVYYD	LIG_APCC_ABBA_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRVYYD

Degron related mutations and impact score

Drug responses associated with STXBP5L mutations

All proteins holding degron of LRVYYD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K9	Syntaxin-binding protein 5-like	LIG_APCC_ABBA_1	245:250	LRVYYD	APC,CDC20,FZR1	0.5651	More...