DegronMD

Uniprot ID: Q9Y2K9

Source protein: Syntaxin-binding protein 5-like

Source gene: STXBP5L

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5593

ASA_SCORE: 69.9222

COIL: 0.4501

CONS_SCORE: 0.3283

DSS_SCORE: 0.5283

HELIX: 0.3564

FCONS_SCORE: 1.1797

RIG_SCORE: 0.798

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G19D	TCGA-AX-A0J0	UCEC	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	0.1944
p.G19D	DO41133	UCEC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	0.1944
p.K8N	TCGA-BS-A0UF	UCEC	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	0.5806
p.K8N	DO41488	UCEC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	0.5806
p.S17Y	TCGA-D3-A3CE	SKCM	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	0.25
p.S17Y	DO37405	SKCM	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	0.25
p.P18T	TCGA-ER-A1A1	SKCM	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	0.2222
p.P18T	DO37413	SKCM	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	0.2222
p.K2N	TCGA-EY-A1GD	UCEC	TCGA	FRKVLDGLT	DEG_APCC_DBOX_1	0.3333
p.K2N	DO42129	UCEC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	0.3333
p.K2N	SIDM01588	Endometrial Carcinoma	GDSC	FRKVLDGLT	DEG_APCC_DBOX_1	0.3333
p.K2N	ACH-000993	Endometrial/Uterine Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	0.3333
p.S16T	DO23362	LINC	ICGC	FRKVLDGLT	DEG_APCC_DBOX_1	0.2778
p.K8I	SIDM00545	Melanoma	GDSC	FRKVLDGLT	DEG_APCC_DBOX_1	0.642
p.K8I	ACH-000987	Skin Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	0.642
p.K8I	Mewo	skin	COSMIC	FRKVLDGLT	DEG_APCC_DBOX_1	0.642
p.S23N	SIDM00660	Colorectal Carcinoma	GDSC	FRKVLDGLT	DEG_APCC_DBOX_1	0.0833
p.S23N	ACH-000985	Colon/Colorectal Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	0.0833
p.S23N	LS-411N	large_intestine	COSMIC	FRKVLDGLT	DEG_APCC_DBOX_1	0.0833
p.S17F	ACH-002024	Colon/Colorectal Cancer	CCLE	FRKVLDGLT	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K9	Syntaxin-binding protein 5-like	DEG_APCC_DBOX_1	6:14	FRKVLDGLT	APC,CDC20,FZR1	0.5593	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons