DegronMD

Uniprot ID: Q9Y2K9

Source protein: Syntaxin-binding protein 5-like

Source gene: STXBP5L

Class: DEG_APCC_DBOX_1

Location: 1079:1087

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5488

ASA_SCORE: 73.6444

COIL: 0.5992

CONS_SCORE: 0.405

DSS_SCORE: 0.4608

HELIX: 0.289

FCONS_SCORE: 1.0532

RIG_SCORE: 0.7628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1081C	TCGA-21-1080	LUSC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.6489
p.G1081C	DO26502	LUSC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.6489
p.G1091R	TCGA-33-AASI	LUSC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.2222
p.G1091R	TCGA-AA-A02R	COAD	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.2222
p.G1091R	DO219129	LUSC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.2222
p.K1084E	TCGA-55-7994	LUAD	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.591
p.L1083F	TCGA-AA-A00N	COAD	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.6981
p.L1083I	TCGA-AX-A0J0	UCEC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.7174
p.F1094S	TCGA-BS-A0UF	UCEC	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.1389
p.F1094S	DO41488	UCEC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.1389
p.F1094L	TCGA-DA-A95Z	SKCM	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.1389
p.E1076Q	TCGA-DK-A6B2	BLCA	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.25
p.E1076Q	DO48543	BLCA	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.25
p.D1095G	TCGA-F5-6814	READ	TCGA	NRGFLKGLF	DEG_APCC_DBOX_1	0.1111
p.D1095G	DO36556	READ	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.1111
p.A1077S	DO229029	LICA	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.2778
p.R1086C	DO222843	MELA	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.8301
p.R1086C	DO43891	UCEC	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.8301
p.L1088I	DO36324	PRAD	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.3056
p.L1088I	LNCaP-Clone-FGC	prostate	COSMIC	NRGFLKGLF	DEG_APCC_DBOX_1	0.3056
p.G1082R	DO37535	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.7568
p.G1082E	DO47288	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.7199
p.G1082E	DO47619	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.7199
p.G1082E	DO51298	SKCM	ICGC	NRGFLKGLF	DEG_APCC_DBOX_1	0.7199
p.F1087I	SIDM00333	Endometrial Carcinoma	GDSC	NRGFLKGLF	DEG_APCC_DBOX_1	0.6304
p.F1087I	ACH-000988	Endometrial/Uterine Cancer	CCLE	NRGFLKGLF	DEG_APCC_DBOX_1	0.6304
p.F1087I	MFE-319	endometrium	COSMIC	NRGFLKGLF	DEG_APCC_DBOX_1	0.6304

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K9	Syntaxin-binding protein 5-like	DEG_APCC_DBOX_1	1079:1087	NRGFLKGLF	APC,CDC20,FZR1	0.5488	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRGFLKGLF

Degron related mutations and impact score

Drug responses associated with STXBP5L mutations

All proteins holding degron of NRGFLKGLF