DegronMD

Uniprot ID: Q9Y2K9

Source protein: Syntaxin-binding protein 5-like

Source gene: STXBP5L

Class: DEG_SCF_FBW7_1

Location: 1068:1074

E3 ligase: FBXW7

DEGRON score: 0.9936

ASA_SCORE: 79.2286

COIL: 0.8094

CONS_SCORE: 0.3468

DSS_SCORE: 0.4304

HELIX: 0.0389

FCONS_SCORE: 0.9262

RIG_SCORE: 0.8174

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1069Y	TCGA-34-2609	LUSC	TCGA	LFTPIET	DEG_SCF_FBW7_1	0.6417
p.T1070A	TCGA-5M-AAT6	COAD	TCGA	LFTPIET	DEG_SCF_FBW7_1	0.7139
p.T1070A	DO223703	COAD	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.7139
p.G1066E	TCGA-90-A4EE	LUSC	TCGA	LFTPIET	DEG_SCF_FBW7_1	0.2778
p.G1066E	DO45513	LUSC	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.2778
p.T1070I	TCGA-AN-A046	BRCA	TCGA	LFTPIET	DEG_SCF_FBW7_1	0.7078
p.D1067Y	TCGA-D5-6928	COAD	TCGA	LFTPIET	DEG_SCF_FBW7_1	0.3056
p.E1076Q	TCGA-DK-A6B2	BLCA	TCGA	LFTPIET	DEG_SCF_FBW7_1	0.2778
p.E1076Q	DO48543	BLCA	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.2778
p.L1059F	DO9876	COAD	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.0833
p.A1077S	DO229029	LICA	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.25
p.K1060E	DO45311	LUAD	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.1111
p.F1070L	DO219481	SKCM	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.6981
p.L1059I	DO41133	UCEC	ICGC	LFTPIET	DEG_SCF_FBW7_1	0.0833
p.F1063I	MFE-319	endometrium	COSMIC	LFTPIET	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K9	Syntaxin-binding protein 5-like	DEG_SCF_FBW7_1	1068:1074	LFTPIET	FBXW7	0.9936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons