DegronMD

Uniprot ID: Q9Y2K9

Source protein: Syntaxin-binding protein 5-like

Source gene: STXBP5L

Class: DEG_SCF_FBW7_2

Location: 566:572

E3 ligase: FBXW7

DEGRON score: 0.7853

ASA_SCORE: 78.9571

COIL: 0.8254

CONS_SCORE: 0.2159

DSS_SCORE: 0.5375

HELIX: 0.0726

FCONS_SCORE: 0.8858

RIG_SCORE: 0.7263

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P576L	TCGA-43-5668	LUSC	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.2222
p.P576L	TCGA-D3-A8GC	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.2222
p.P576L	DO26608	LUSC	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.2222
p.P576L	DO50281	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.2222
p.L580P	TCGA-91-6836	LUAD	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.1111
p.L580P	DO23854	LUAD	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.1111
p.I566V	TCGA-AP-A0LM	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.5965
p.I566V	DO43306	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.5965
p.P578T	TCGA-AX-A05Z	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.1667
p.P578T	DO40884	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.1667
p.V563A	TCGA-B5-A11E	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.25
p.V563A	TCGA-W3-AA1Q	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.25
p.V563A	DO219487	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.25
p.V563A	DO41644	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.25
p.P576S	TCGA-DA-A3F8	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.2222
p.P576S	DO37418	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.2222
p.P575S	TCGA-EE-A3JD	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.25
p.P575S	DO50299	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.25
p.L580F	TCGA-ER-A19G	SKCM	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.1111
p.L580F	DO47284	SKCM	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.1111
p.R558Q	TCGA-FI-A2D0	UCEC	TCGA	IITPEPE	DEG_SCF_FBW7_2	0.1111
p.R558Q	DO43891	UCEC	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.1111
p.E556Q	DO50403	ESAD	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.0556
p.E564G	DO234356	ESAD	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.2778
p.T573R	DO228667	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.3056
p.Q560H	DO229034	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.1667
p.V563F	DO229034	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.25
p.V557L	DO229041	LICA	ICGC	IITPEPE	DEG_SCF_FBW7_2	0.0833
p.R558P	ACH-001698	Head and Neck Cancer	CCLE	IITPEPE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K9	Syntaxin-binding protein 5-like	DEG_SCF_FBW7_2	566:572	IITPEPE	FBXW7	0.7853	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IITPEPE

Degron related mutations and impact score

Drug responses associated with STXBP5L mutations

All proteins holding degron of IITPEPE