DegronMD - A6NMT0(DBX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R272C	TCGA-2W-A8YY	CESC	TCGA	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1111
p.F200L	TCGA-38-4625	LUAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0556
p.F200L	DO23952	LUAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0556
p.F262Y	TCGA-62-A46R	LUAD	TCGA	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.7528
p.F262Y	DO45355	LUAD	ICGC	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.7528
p.G322V	TCGA-63-A5MS	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.F146L	TCGA-63-A5MW	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0556
p.F146L	DO219169	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0556
p.K265R	TCGA-86-6851	LUAD	TCGA	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.3056
p.T20M	TCGA-AJ-A5DW	UCEC	TCGA	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.7423
p.T20M	DO50075	UCEC	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.7423
p.S152Y	TCGA-AP-A059	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2222
p.S152Y	DO41361	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2222
p.A157S	TCGA-BA-A6DA	HNSC	TCGA	PASSS	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.6477
p.A157S	DO44448	HNSC	ICGC	PASSS	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.6477
p.E315K	TCGA-BR-8361	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7022
p.E315K	TCGA-D3-A5GS	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7022
p.D190N	TCGA-BS-A0UF	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6932
p.D190N	TCGA-EO-A22X	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6932
p.D190N	DO43907	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6932
p.D190N	DO41488	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6932
p.R179Q	TCGA-CK-5913	COAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1944
p.R179Q	TCGA-D1-A16J	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1944
p.R179Q	DO8826	COAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1944
p.R179Q	DO43033	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1944
p.A61T	TCGA-D5-6531	COAD	TCGA	PPAY	ITCH	50:53	Mutation rewiring degron network	0.1111
p.A61T	DO7983	COAD	ICGC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.1111
p.A61T	DO233093	GACA	ICGC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.1111
p.Q309H	TCGA-DK-AA6S	BLCA	TCGA	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.M273I	TCGA-EE-A3J5	SKCM	TCGA	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.0833
p.F200Y	TCGA-EY-A1GD	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0556
p.F200Y	DO42129	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0556
p.R175C	TCGA-FI-A2D5	UCEC	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0833
p.R175C	DO41331	UCEC	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0833
p.F188L	TCGA-HF-A5NB	STAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6981
p.F188L	DO229019	LICA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6981
p.F188L	DO50127	STAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6981
p.M63I	TCGA-L5-A8NF	ESCA	TCGA	PPAY	ITCH	50:53	Mutation rewiring degron network	0.0556
p.A8V	TCGA-UT-A88E	MESO	TCGA	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.0833
p.A174T	TCGA-VQ-A91K	STAD	TCGA	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0556
p.A174T	DO51785	STAD	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.0556
p.Q270H	DO219007	BLCA	ICGC	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1667
p.Q270H	ACH-001336	Cervical Cancer	CCLE	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1667
p.F168L	DO10324	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1111
p.P165T	DO230343	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1944
p.A186T	DO222492	COCA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation altering degron motif	0.6028
p.A11S	DO50449	ESAD	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.1667
p.A11S	ACH-000258	Breast Cancer	CCLE	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.1667
p.R56H	DO234200	ESAD	ICGC	PPAY	ITCH	50:53	Mutation rewiring degron network	0.25
p.R193W	DO233088	GACA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.25
p.A314T	DO233090	GACA	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7139
p.A314T	DO43602	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7139
p.S312L	DO14373	HNSC	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.S312L	DO38006	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.D324E	DO229037	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.A195E	DO229009	LICA	ICGC	RRAVFSD	LIG_APCC_ABBAyCdc20_2	184:190	Mutation rewiring degron network	0.1944
p.P163S	DO22836	LIHC	ICGC	PASSS	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.25
p.P322T	DO23932	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.P308L	DO26337	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1667
p.S34F	DO222578	MELA	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.0556
p.P254S	DO217836	ORCA	ICGC	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.1944
p.S160I	DO232224	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7341
p.G320R	DO47667	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.P311L	DO219481	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.A314V	DO38887	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.5825
p.A314V	SIDM00499	Prostate Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.5825
p.A314V	ACH-000956	Prostate Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.5825
p.A314V	22RV1	prostate	COSMIC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.5825
p.P9L	DO229259	THCA	ICGC	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.1111
p.F325L	DO43154	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1389
p.H315Y	DO42560	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6118
p.P261S	DO43755	UCEC	ICGC	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.6752
p.S328A	DO42472	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.L259F	DO42472	UCEC	ICGC	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.587
p.L259F	ACH-001618	Leukemia	CCLE	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.587
p.P50R	SIDM00629	Breast Carcinoma	GDSC	PPAY	ITCH	50:53	Mutation altering degron motif	0.7512
p.H262Y	SIDM00721	Small Cell Lung Carcinoma	GDSC	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.6118
p.H262Y	ACH-002171	Lung Cancer	CCLE	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.6118
p.H262Y	NCI-H250	lung	COSMIC	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation altering degron motif	0.6118
p.S28F	SIDM01059	Melanoma	GDSC	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation rewiring degron network	0.2222
p.P256H	ACH-001111	Lymphoma	CCLE	LNPHPD	LIG_APCC_ABBA_1	259:264	Mutation rewiring degron network	0.25
p.R18L	ACH-002066	Sarcoma	CCLE	LRPTPTLT	DEG_SCF_FBW7_1	17:24	Mutation altering degron motif	0.7316

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DBX1

UniProt ID: A6NMT0

Entrez ID: 120237

Protein name: Homeobox protein DBX1 (Developing brain homeobox protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DBX1 in