DegronMD

Uniprot ID: A6NMT0

Source protein: Homeobox protein DBX1

Source gene: DBX1

Class: DEG_SPOP_SBC_1

Location: 314:318

E3 ligase: SPOP

DEGRON score: 0.9343

ASA_SCORE: 76.86

COIL: 0.9496

CONS_SCORE: 0.2932

DSS_SCORE: 0.8656

HELIX: 0.0418

FCONS_SCORE: 0.9589

RIG_SCORE: 0.4181

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G322V	TCGA-63-A5MS	LUSC	TCGA	AHSSS	DEG_SPOP_SBC_1	0.2222
p.E315K	TCGA-BR-8361	STAD	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7022
p.E315K	TCGA-D3-A5GS	SKCM	TCGA	AHSSS	DEG_SPOP_SBC_1	0.7022
p.Q309H	TCGA-DK-AA6S	BLCA	TCGA	AHSSS	DEG_SPOP_SBC_1	0.1944
p.A314T	DO233090	GACA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7139
p.A314T	DO43602	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.7139
p.S312L	DO14373	HNSC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.S312L	DO38006	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.D324E	DO229037	LICA	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1667
p.P322T	DO23932	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2222
p.P308L	DO26337	LUAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1667
p.G320R	DO47667	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.2778
p.P311L	DO219481	SKCM	ICGC	AHSSS	DEG_SPOP_SBC_1	0.25
p.A314V	DO38887	STAD	ICGC	AHSSS	DEG_SPOP_SBC_1	0.5825
p.A314V	SIDM00499	Prostate Carcinoma	GDSC	AHSSS	DEG_SPOP_SBC_1	0.5825
p.A314V	ACH-000956	Prostate Cancer	CCLE	AHSSS	DEG_SPOP_SBC_1	0.5825
p.A314V	22RV1	prostate	COSMIC	AHSSS	DEG_SPOP_SBC_1	0.5825
p.F325L	DO43154	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.1389
p.H315Y	DO42560	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.6118
p.S328A	DO42472	UCEC	ICGC	AHSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15015	Zinc finger protein 646	DEG_SPOP_SBC_1	903:907	AHSSS	SPOP	0.9691	More...
O60269	G protein-regulated inducer of neurite outgrowth 2	DEG_SPOP_SBC_1	206:210	AHSSS	SPOP	0.855	More...
O95425	Supervillin	DEG_SPOP_SBC_1	249:253	AHSSS	SPOP	0.9277	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	464:468	AHSSS	SPOP	0.8527	More...
Q13416	Origin recognition complex subunit 2	DEG_SPOP_SBC_1	246:250	AHSSS	SPOP	0.8711	More...
Q13586	Stromal interaction molecule 1	DEG_SPOP_SBC_1	397:401	AHSSS	SPOP	0.9518	More...
Q6UVJ0	Spindle assembly abnormal protein 6 homolog	DEG_SPOP_SBC_1	498:502	AHSSS	SPOP	0.9472	More...
Q05952	Nuclear transition protein 2	DEG_SPOP_SBC_1	62:66	AHSSS	SPOP	0.9869	More...
Q8IX06	Putative exonuclease GOR	DEG_SPOP_SBC_1	211:215	AHSSS	SPOP	0.5387	More...
Q8WYN3	Cysteine/serine-rich nuclear protein 3	DEG_SPOP_SBC_1	297:301	AHSSS	SPOP	0.8601	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	1445:1449	AHSSS	SPOP	0.9988	More...
A6NMT0	Homeobox protein DBX1	DEG_SPOP_SBC_1	314:318	AHSSS	SPOP	0.9343	More...
C9J798	Ras GTPase-activating protein 4B	DEG_SPOP_SBC_1	782:786	AHSSS	SPOP	0.6288	More...
Q2WGJ9	Fer-1-like protein 6	DEG_SPOP_SBC_1	1123:1127	AHSSS	SPOP	0.7335	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	422:426	AHSSS	SPOP	0.9446	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	694:698	AHSSS	SPOP	0.9817	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	76:80	AHSSS	SPOP	0.9484	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons